1 504株鲍曼不动杆菌的临床分布及耐药性分析

J4 ›› 2010, Vol. 36 ›› Issue (3): 574-577.

1 504株鲍曼不动杆菌的临床分布及耐药性分析

沈煜¹ 王春梅¹ 尚静² 李燕²

(1.首都医科大学宣武医院血管外科ICU, 北京 |100053;2.首都医科大学宣武医院检验科细菌室, 北京 |100053)

收稿日期:2010-02-23 出版日期:2010-05-28 发布日期:2010-05-28
通讯作者: 沈煜 E-mail:shenyu1905@hotmail.com
作者简介:沈煜（1970-）|男|北京市人|主治医师|医学学士|主要从事ICU相关研究。
基金资助:
首都医学发展基金资助课题（2007-3110）

Clinical distribution and resistance characteristic analysis of |1 504 Acinetobacter baumannii strains

CHEN Yu¹ WANG Chun-Mei¹ CHANG Jing² LI Yan²

(1.Department of Vascular Surgery ICU,Xuanwu Hospital,Beijing Capital Medical University,Beijing 100053,China|2.Department of Inspection Bacteria Room, Xuanwu Hospital,Beijing Capital Medical University,Beijing 100053,China)

Received:2010-02-23 Online:2010-05-28 Published:2010-05-28

摘要/Abstract

摘要：

目的：对鲍曼不动杆菌（Ab）的临床分布及耐药性情况进行分析，以期为临床防治提供参考。方法：资料来源于首都医科大学宣武医院2006年1月—2009年10月经细菌培养培养出Ab的临床标本共1　504例，对其临床分布及耐药性情况进行分析。结果：Ab主要分离于重症监护病房(ICU)和急诊病房的送检标本, ICU　665株（44.2%），急诊病房123株（8.2%），其他各科室普通病房716株（47.6%）。痰标本检出率最高，为1 304株（89.6%）。Ab对几乎所有抗生素的耐药性呈逐年上升的趋势，以亚胺培南（IPM）最为明显，IPM的耐药性于2009年已达71.8%，但仍是本院治疗Ab最为敏感的抗生素（敏感性为28%）。因2006年耐药性为100%而于2007年减少应用的头孢噻肟，在2008年重新应用时耐药性降低至33.3%，敏感性增至33.3%。已出现多重耐药Ab。结论：Ab主要分布于ICU，碳青霉酶烯类抗生素是本院治疗Ab感染最敏感的药物。一定时期内停用某一耐药性高的药物可增强Ab对其的敏感性。

关键词: 鲍曼不动杆菌；耐药性

Abstract:

Abstract:Objective
To analysis the clinical distribution and resistance characteristics in isolates of Acinetobacter baumannii(Ab), and provide evidence for clinical prevention and therapy. Methods 1 504 Ab strains were isolated from clinical specimens in Xuanwu Hospital of Beijing Capital Medical Univercity from January, 2006 to October, 2009. The clinical distribution and the resistance results of Ab were analyzed retrospectively. Results The majority of these Ab strains was distributed in ICUs(665 strains, account for 44.2%) and emergency wards(123 strains, account for 8.2%). Other common wards isolated 716 strains(account for 47.6%). The majority of these Ab strains was isolated from sputum(1 304 strains, account for 89.6%). The resistance of Ab showed the rising tendency to all kinds of antibiotics, especially to imipenem. Despite the resistance rate of imipenem acquired 71.8% in 2009, it was the most sensitive drug of treating Ab(the sensitivity was 28%).The resistance rate of cefotaxime(CTX) was 100% in 2006, whose application was decreased in 2007, but decrea
sed to 33.3% in 2008. Multi-drug resistance Ab had been emerged. Conclusion The majority of Ab distributes in ICU.Carbapenems are the most sensitive drugs of treating Ab. If a highly resistant drug is stopped using over a period of time, the sensitivity of Ab to antibiotic may be increased.

Key words: Acinetobacter baumannii; , resistance characteristic

中图分类号:

R378

沈煜, 王春梅, 尚静, 李燕. 1 504株鲍曼不动杆菌的临床分布及耐药性分析[J]. J4, 2010, 36(3): 574-577.

CHEN Yu, WANG Chun-Mei, CHANG Jing, LI Yan. Clinical distribution and resistance characteristic analysis of |1 504 Acinetobacter baumannii strains[J]. J4, 2010, 36(3): 574-577.