5-羟色胺1A受体基因多态性与自杀关联性的Meta分析

J4 ›› 2010, Vol. 36 ›› Issue (6): 1134-1138.

5-羟色胺1A受体基因多态性与自杀关联性的Meta分析

俞琼|付颖利|冯佳|谢冰|寇长贵|于雅琴

吉林大学公共卫生学院流行病与卫生统计学教研室,吉林长春 130021

收稿日期:2010-09-26 出版日期:2010-11-28 发布日期:2010-11-28
通讯作者: 于雅琴（Tel:0431-85619437，E-mail: yuyaqin5540@163.com） E-mail:yuyaqin5540@163.com
作者简介:俞琼（1978-）|女|浙江省绍兴市人|讲师|医学博士|主要从事分子遗传学和分子流行病学研究。
基金资助:
国家自然科学基金资助课题（30901229）；吉林大学大学生创新性实验计划国家级资助课题（2009A72076）

Meta analysis |on |relationship between 5-hydroxytryptamine 1A receptor gene polymorphism and suicide

YU Qiong,FU Ying-li,FENG Jia,XIE Bing,KOU Chang-gui,YU Ya-qin

Department of Epidemiology and Health Statistics,School of Public Health,Jilin |University,Changchun 130021,China

Received:2010-09-26 Online:2010-11-28 Published:2010-11-28

摘要/Abstract

摘要：

目的：用Meta分析的方法综合评价人群中5-羟色胺1A受体（5-HT1A receptor）基因rs6295多态性与自杀行为的关联性。方法：通过计算机检索PubMed、Cochorane、CNKI和万方数据库，搜集有关5-HT1A 受体基因rs6295多态性与自杀关联性的全文文献。以病例组和对照组5-HT1A受体基因分布的OR及其95 %CI为效应指标，在全面文献回顾的基础上对文献进行筛选、评价和数据提取。应用Rev Man 5.0软件对各研究原始数据进行统计分析，包括异质性检验、合并效应量以及评估发表偏倚。结果共6篇符合条件的文献被纳入分析，因研究文献中自杀行为包括自杀死亡和自杀未遂，故依据研究内容从6篇纳入文献中提取出7项单独研究进行Meta分析。总体自杀行为基因型Meta 分析结果合并OR=1.27，95%CI=0.93~1.74,P>0.05，等位基因Meta 分析结果合并OR=1.15,95%CI=0.91~1.45,P>0.05;自杀未遂者基因型Meta 分析结果合并OR=1.12,95%CI=0.84~1.49,P>0.05,等位基因Meta 分析结果合并OR=1.04,95%CI=0.87~1.24,P>0.05;自杀死亡者基因型Meta 分析结果合并OR=1.53,95%CI=1.10~2.14,P<0.01,等位基因Meta 分析结果合并OR=1.57,95%CI=0.66~3.71，P>0.05。结论:人群中5-HT1A受体基因rs6295态性与自杀行为无关联而与自杀死亡的发生有关联。

关键词: 自杀；5-羟色胺1A受体；多态性；Meta分析

Abstract:

Abstract:Objective To evaluate the association of 5-hydroxytryptamine 1A receptor gene( 5-HT1A receptor gene) rs6295 polymorphism and suicide with Meta-analysis. Methods PubMed,Cochorane,CNKI and Wanfang Database were used to search all the relevant case-control trials about the association of 5-HT1A receptor gene rs6295 polymorphism and suicide. Statistical analysis was performed with RevMan5.0 including the heterogeneity inspection, effect consoliating and evaluatation on publication bias. Results A total of 6 articles were included after the analysis.Because suicide in the literature included suicide attempters and suicide completers, 7 independent studies were selected. Overall the results of suicide genotype Meta analysis were listed as follows: OR=1.27，95 %CI=0.93-1.74,P>0.05，suicide alleles were OR=1.15,95 %CI=0.91-1.45,P>0.05.The Meta analysis results of suicide attempter genotype were listed as follows: OR=1.12,95 %CI=0.84-1.49,P>0.05;suicide attempter alleles OR=1.04,95 %CI=0.87-1.24,P>0.05.The Meta analysis results of suicide completer genotypes were listed as follows: OR=1.53,95 %CI=1.10-2.14,P<0.01,suicide completer alleles were OR=1.57,95 %CI=0.66-3.71，P>0.05.Conclusion The Meta analysis results show that the 5- HT1A receptor gene rs6295 polymorphisms are not associated with suicide attempters but associated with suicide completers.

Key words: suicide;5-hydroxytryptamine 1A receptor;polymorphism;Meta analysis

中图分类号:

俞琼|付颖利|冯佳|谢冰|寇长贵|于雅琴. 5-羟色胺1A受体基因多态性与自杀关联性的Meta分析[J]. J4, 2010, 36(6): 1134-1138.

YU Qiong,FU Ying-li,FENG Jia,XIE Bing,KOU Chang-gui,YU Ya-qin. Meta analysis |on |relationship between 5-hydroxytryptamine 1A receptor gene polymorphism and suicide[J]. J4, 2010, 36(6): 1134-1138.