UTS2-S89N基因多态性与东乡族原发性高血压患者血脂水平关联性分析

J4 ›› 2011, Vol. 37 ›› Issue (5): 890-893.

UTS2-S89N基因多态性与东乡族原发性高血压患者血脂水平关联性分析

伊琳

甘肃中医学院中西医结合系,甘肃兰州 730000

收稿日期:2011-05-11 出版日期:2011-09-28 发布日期:2011-09-28
通讯作者: 伊琳(Tel:0931-8765463,E-mail:yxxxlyyy@163.com) E-mail:yxxxlyyy@163.com
作者简介:伊琳（1971-）|女|陕西省三原县人|副教授|医学博士|主要从事原发性高血压基因多态性方面的研究。
基金资助:
甘肃省科技厅自然科学基金资助课题（1010RJZA158）

Analysis on association between urotensin ⅡS89N gene polymorphisms and serum lipid level in essential hypertension patients in Dongxiang population

YI Lin

Department of Cooperation of Chinese and Western Medicine,Gansu College of |Traditional Chinese Medicine,Lanzhou 730000,China

Received:2011-05-11 Online:2011-09-28 Published:2011-09-28

摘要/Abstract

摘要：

目的：研究硬骨鱼紧张素ⅡS89N基因（UTS2-S89N）单核苷酸多态性（SNP）与东乡族原发性高血压(EH)患者血脂的关系。方法：采用PCR-RFLP及电泳分析法对东乡族102例健康个体（对照组）及120例EH患者（病例组）进行基因分型；全自动生化仪测定血脂水平；分析各基因型与东乡族人群EH患者血脂水平的关联性。结果：东乡族EH患者的TC、TG和LDL-C均高于对照组(P<0.01)。在病例组患者中，携带SS基因型患者的LDL-C水平 (2.76±1.02)mmol/L显著高于NN基因型（2.34±0.37）mmol/L和NS基因型（2.12±0.65）mmol/L-1差异有统计学意义(P<0.05)，而在正常对照组则无此差异。TC、TG和HDL-C水平在病例组与对照组各基因型之间差异均无统计学意义（P>0.05）。结论：UTS2-S89N 基因SS基因型与东乡族EH患者血脂水平升高存在关联性。

关键词: 东乡族；血脂；原发性高血压；单核苷酸多态性, 硬骨鱼紧张素Ⅱ基因

Abstract:

Abstract:Objective To study the association between urotensin Ⅱ (UTS2) S89N gene single nucleotide polymorphism(SNP) and serum lipid level in essential hypertension(EH) patients in Dongxiang population.Methods The genotypes of UTS2-S89N of 102 normal persons(control group) and 120 EH patients (case group) were conducted by PCR -RFLP and agarose gel electrophoretic analysis.The serum lipid levels was detected by automatic biochemical analyzer.The association between genotypes of UTS2-S89N and the serum lipid level in Dongxiang population was analyzed.Results The levels of TC,TG,and LDL-C in case group.were higher than those in control group(P<0.01).In case group,the level of LDL-C of the patients with SS gentype(2.76±1.02) was higher than those of the patients with NN genotype(2.34±0.37) and NS genotype (2.12±0.65)(P<0.05).The levels of TC,TG and HDC-C had no significnat differences between various genotypes in two groups(P>0.05).Conclusion The SS genotype of UTS2-S89N gene is associated with the serum lipid of the EH patients in Dongxiang population.

Key words: Dongxiang population;serum lipid;essential hypertension;single nucleotide polymorphism;urotensin Ⅱ gene

中图分类号:

R544.1

伊琳. UTS2-S89N基因多态性与东乡族原发性高血压患者血脂水平关联性分析[J]. J4, 2011, 37(5): 890-893.

YI Lin . Analysis on association between urotensin ⅡS89N gene polymorphisms and serum lipid level in essential hypertension patients in Dongxiang population[J]. J4, 2011, 37(5): 890-893.

[1]	吴海帝\|徐国良\|秦玲. 厄贝沙坦氢氯噻嗪复方制剂治疗原发性高血压有效性及安全性的Meta分析[J]. J4, 2011, 37(3): 517-522.
[2]	杨丽, 吴源, 杨萍. 高血压病患者血小板活化标志物和凝血活性的检测及临床意义[J]. J4, 2009, 35(5): 923-927.