GRIM-19及其靶基因产物STAT3在十二指肠癌中的表达及其意义

J4 ›› 2011, Vol. 37 ›› Issue (6): 1094-1097.

GRIM-19及其靶基因产物STAT3在十二指肠癌中的表达及其意义

刘岩,李静,张照果

辽宁医学院附属第一医院消化科|辽宁锦州 |121000

收稿日期:2011-06-22 出版日期:2011-11-28 发布日期:2011-11-28
通讯作者: 李静（Tel:0416-4197540,E-mail:jz7203@yahoo.com.cn） E-mail:jz7203@yahoo.com.cn
作者简介:刘岩（1984-）|女|辽宁省铁岭市人|在读医学硕士|主要从事胃肠道肿瘤的早期诊断研究。
基金资助:
辽宁省科技厅博士启动基金资助课题（20101064）

Expressions of GRIM-19 and its target gene product STAT3 in duodenum carcinoma and their significances

LIU Yan,LI Jing|ZHANG Zhao-guo

Department of Digestive Medicine,First Affiliated Hospital|Liaoning Medical University,Jinzhou 121000,China

Received:2011-06-22 Online:2011-11-28 Published:2011-11-28

摘要/Abstract

摘要：

目的：研究干扰素/ 维甲酸联合应用诱导细胞凋亡相关基因-19（GRIM-19）及其靶基因产物信号转导和转录活化因子3（STAT3）在十二指肠癌中的表达，探讨其在十二指肠癌发生和发展中的作用。方法：32例十二指肠癌组织和30例十二指肠炎及溃疡对照组织，采用免疫组织化学方法检测其GRIM-19及STAT3蛋白表达情况。结果：十二指肠癌组织GRIM-19蛋白表达水平较十二指肠炎及溃疡组织表达减弱(P<0.05)，且与十二指肠癌的分化程度有关(P<0.01)；十二指肠癌组织STAT3蛋白表达水平较十二指肠炎及溃疡组织表达增强(P<0.01)，且与十二指肠癌的分化程度及淋巴结转移有关(P<0.01)；十二指肠癌组织中GRIM-19与STAT3表达呈负相关(r=－0.470，P<0.01)。结论：GRIM-19 蛋白在十二指肠癌组织中的低表达或缺失与十二指肠癌的发生和发展密切相关。十二指肠癌组织中有GRIM-19低表达与STAT3高表达共存现象。

关键词: 干扰素/ 维甲酸联合应用诱导细胞凋亡相关基因-19；信号转导和转录活化因子3；十二指肠肿瘤；免疫组织化学

Abstract:

Objective

To investigate the expressions of gene associated with retinoid-interferon mortality-19 (GRIM-19) and its target gene product signal transducers and activator of transcription 3(STAT3)in human duodenum carcinomas,and study their effects in occurrence and development of duodenum carcinoma. Methods 32 specimens of duodenum carcinomas,30 specimens of duodenal gastritis and ulcer tissue were included in this study.The expressions of GRIM-19 and STAT3 protein were determined by immunohistochemistry.Results The protein expression of GRIM-19 in duodenum carcinoma tissues were obviously lower than that in duodenal gastritis and ulcer tissues (P<0.05);furthermore,the protein expression of GRIM-19 was correlated to cell differentiation(P<0.01).The protein expression of STAT3 in duodenum carcinoma tissues were obviously higher than that in duodenal gastritis and ulcer tissues (P<0.01),and the expression of STAT3 was correlated to cell differentiation and lymphatic metastasis(P<0.01).The significantly negative correlation was found between the expression of GRIM-19 and STAT3 in duodenum carcinoma tissues(r=－0.470，P<0.01). Conclusion The low expression or absence of GRIM-19 may play an important role in the tumorigenesis of duodenum carcinoma.The low expression of GRIM-19 and the high expression of STAT3 co-exist in duodenum carcinoma tissues.

Key words: gene associated with retinoid-interferon mortality-19;signal transducers and activator of transcription 3;duodenum neoplasms;immunohistochemistry

中图分类号:

Q691

刘岩,李静,张照果 . GRIM-19及其靶基因产物STAT3在十二指肠癌中的表达及其意义[J]. J4, 2011, 37(6): 1094-1097.

LIU Yan,LI Jing|ZHANG Zhao-guo . Expressions of GRIM-19 and its target gene product STAT3 in duodenum carcinoma and their significances[J]. J4, 2011, 37(6): 1094-1097.