基于多腔型压电驱动血泵血液相容性的体外观察

J4 ›› 2012, Vol. 38 ›› Issue (4): 640-643.

基于多腔型压电驱动血泵血液相容性的体外观察

苏静¹|周磊²|董景石³|郭丽荣¹|林柏松⁴

1.吉林大学白求恩医学院病理生理学系|吉林长春 130021；2.长春中医药大学附属医院病理科|吉林长春 130021；3.吉林大学机械科学与工程学院链条传动所|吉林长春 130025；4.吉林大学中日联谊医院心外科|吉林长春 130033)

收稿日期:2012-02-29 出版日期:2012-07-28 发布日期:2012-07-28
通讯作者: 林柏松 E-mail:（Tel:0431-85619485，E-mail：denticle615@hotmail.com）
作者简介:苏静（1978-）|女|吉林省长春市人|讲师|医学博士|主要从事心血管病理生理学研究。
基金资助:
国家自然科学基金面上项目资助课题（81171481）；吉林大学基本科研业务费科学前沿与交叉学科创新项目资助课题（200903003）

Blood compatibility of multi-chamber piezoelectric pump in vitro

SU Jing¹|ZHOU Lei²|DONG Jing-shi³|GUO Li-rong¹|LIN Bai-song⁴

(1.Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China；2.Department of Pathology,Affiliated Hospital, Changchun University of Chinese　Medicine,Changchun 130021,China；3.College of Mechanical Science and Engineering,Jilin University,Changchun 130025,China；4.Department of Cardiovascular Surgery,China-Japan Union Hospital,Jilin University,Changchun 130033,China)

Received:2012-02-29 Online:2012-07-28 Published:2012-07-28

摘要/Abstract

摘要：

目的：研究以多腔压电泵驱动血液时对血细胞和凝血系统的影响。方法：建立体外模拟循环系统，以抗凝犬血为测试介质；压电泵驱动循环时间分为0、1和2 h，并设立对照组；检测血液中血红蛋白浓度、白细胞、红细胞、血小板计数及红细胞比容，计算溶血指标(IH)。结果：与对照组比较，循环0 h各指标差异无统计学意义(P>0.05)；循环1和2 h时，红细胞、白细胞、血小板计数、血红蛋白浓度及红细胞比容均降低（P<0.05）。与对照组比较，循环1和2 h时，游离血红蛋白浓度增高(P<0.05),纤维蛋白原浓度降低（P<0.05）。但循环1 h与2 h比较，上述各指标差异无统计学意义（P＞0.05）。计算得到压电泵IH为0.004 5，明显低于国际标准溶血指标允许值0.1。结论：压电泵虽对血液成分和溶血有影响，但随循环时间延长该影响并不加重，IH在国际标准允许值范围内，表明其在体外实验中具有良好的血液相容性。

关键词: 血液相容性；多腔压电泵；血泵

Abstract:

Abstract:Objective
To explore the influence of multi-chamber piezoelectric pump on the blood cells and coagulation system when it applied as blood driving pump. Methods Anticoagulation dog blood was utilized as circulating medium in the simulative circulatory system. There were three groups depended on the circulation time (0,1 and 2 h) and a control group. Hemoglobin concentration,white blood cell,red blood cell and platelet counts,hematocrit,free hemoglobin concentration were detected. The index of hemolysis (IH) of multi-chamber piezoelectric pump was calculated as an important index of hemolysis damage. Results Compared with control group,each index was not significantly changed in cycle 0 h group(P>0.05). Compared with control group,the red blood cell count,white blood cell count,platelet count,hemoglobin concentration,hematocrit were decreased in cycle 1 h and 2 h groups（P<0.05). Compared with control group,the free hemoglobin concentration was increased,the fibrinogen concentration was decreased（P<0.05）. Compared with cycle 1 h group,each index was not significantly changed in cycle 2 h group（P＞0.05）.The IH of pump was calculated as 0.004 5,and it was significantly lower than international standard(＜0.1). Conclusion Multi-chamber piezoelectric pump has good blood compatibility in vitro. It has advantages to apply as blood-driving pump.

Key words: blood compatibility, multi-chamber piezoelectric pump, blood pump

中图分类号:

R318.11

苏静|周磊|董景石|郭丽荣|林柏松. 基于多腔型压电驱动血泵血液相容性的体外观察[J]. J4, 2012, 38(4): 640-643.

SU Jing|ZHOU Lei|DONG Jing-shi|GUO Li-rong|LIN Bai-song. Blood compatibility of multi-chamber piezoelectric pump in vitro[J]. J4, 2012, 38(4): 640-643.