吉林大学学报(医学版)

• 基础研究 • 上一篇    下一篇

肺癌患者吸烟与p53基因突变关联性的Meta分析

林雪君1,颜康康1,赵龙宇1,鲍红红1,李 双1,刘晓冬2,刘 欣1   

  1. 1.吉林大学公共卫生学院流行病与卫生统计学教研室,吉林 长春130021; 2.吉林大学
    公共卫生学院卫生部放射生物学重点实验室,吉林 长春130021
  • 收稿日期:2013-10-31 出版日期:2014-09-28 发布日期:2014-11-24
  • 通讯作者: 刘 欣 (Tel:0431-85619431,E-mail:xliu@jlu.edu.cn) E-mail:xliu@jlu.edu.cn
  • 作者简介:林雪君(1989-),女,吉林省敦化市人,在读医学硕士,主要从 事医学统计学研究。
  • 基金资助:

    吉林省科技厅科研基金资助课题(201205008);吉林大学白求恩医学部医学
    科研支持计划青年科研基金资助课题(2013202013)

Meta-analysis on association between smoking and p53
gene mutation in patients with lung cancer


LIN Xue-jun1,YAN Kang-kang1,ZHAO Long-yu1,BAO Hong-hong1,LI Shuang1,LIU Xiao-dong2,LIU Xin1   

  1. 1.Department of Epidemiology and Health Statistics,School of Public Health,Jilin University,Changchun 130021,China;2.Key Laboratory of Radiobiology,Ministry of Health,School of Public Health,Jilin University,Changchun 130021,China
  • Received:2013-10-31 Online:2014-09-28 Published:2014-11-24

摘要:

目的:采用Meta分析的方法综合评价肺癌患者吸烟与p53基因突变的关联性。 方法:全面检索PubMed、Web of Science、ProQuest和Medline数据库,收集有关肺癌患者吸烟与p53基因突变关系研究的文献。在全面文献回顾的基础上对文献进行筛选、评价和数据提取。采用Stata 12.0软件对纳入文献进行Meta分析,包括异质性检验、评估文献发表偏倚、敏感性分析、合并效应量及累积Meta分析。 结果:本研究共纳入15篇文献,包含1 770
名肺癌患者,其中69.6%为吸烟者,30.4%为非吸烟者。异质性检验未发现各研究间存在明显异质性。肺癌患者吸烟与p53基因突变关系的合并OR=2.70,95%CI=2.04~3.59。 结论:肺癌患者吸烟与p53基因突变有关联性;与非吸烟者比较,吸烟者的p53基因突变风险高。

关键词:  , 肺肿瘤;吸烟;p53基因突变;Meta分析

Abstract:

Objective To evaluate the relationship between smoking and p53 gene mutation in the lung cancer patients with Meta-analysis.
Methods PubMed,Web of Science,ProQest and Medline were used to search all the relevant studies about
 the association between smoking and p53 gene mutation in the patients with lung cancer.Based on reviewing full text,the studies were selected and evaluated and the data was extracted.Statistical analysis was performed with Stata 12.0 software including the heterogeneity inspection,publication bias assessment,sensitivity analysis,effect consolidating and cumulative Meta-analysis.Results Totally 15 articles with 1 770 lung cancer patients were identified. 69.6% of the patients were smokers,30.4% were non-smokers.Overall,the smokers with lung cancer had a 2.70-fold higher risk for p53 gene mutation than the non-smokers with lung cancer (OR=2.70,95%CI=2.04-3.59).Conclusion p53 gene mutation is associated with smoking in the patients with lung cancer.The smokers with lung cancer have higher risk for p53 mutation than non-smokers.

Key words:  , lung neoplasms, smoking, p53 gene mutation, Meta-analysis

中图分类号: 

  • R734.2