低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价

doi:10.13481/j.1671-587x.20150531

吉林大学学报(医学版) ›› 2015, Vol. 41 ›› Issue (05): 1032-1035.doi: 10.13481/j.1671-587x.20150531

低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价

钟淑霞¹, 陶育纯², 周俊峰¹, 姚蕾¹, 刘媛媛¹, 闫冬雪¹, 李珊山¹

1. 吉林大学第一医院皮肤科, 吉林长春 130021;
2. 吉林大学公共卫生学院流行病与卫生统计学教研室, 吉林长春 130021

收稿日期:2015-04-10 发布日期:2015-09-29
通讯作者: 李珊山,教授,博士研究生导师(Tel:0431-88782615,E-mail:shansalee@163.com) E-mail:shansalee@163.com
作者简介:钟淑霞(1966-),女,吉林省榆树市人,主治医师,医学硕士,主要从事医学激光治疗皮肤病的基础和临床方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题(3D513U003428)

Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma

ZHONG Shuxia¹, TAO Yuchun², ZHOU Junfeng¹, YAO Lei¹, LIU Yuanyuan¹, YAN Dongxue¹, LI Shanshan¹

1. Department of Dermatology, First Hospital, Jilin University, Changchun 130021, China;
2. Department of Epidemiology and Health Statistics, School of Public Health, Jilin University, Changchun 130021, China

Received:2015-04-10 Published:2015-09-29

摘要/Abstract

摘要：

目的:探讨低剂量普萘洛尔联合1 064 nmNd:YAG激光治疗混合型和深层婴儿血管瘤(IH)的疗效和安全性。方法:60例混合型和深层IH患儿,按照随机数字表分为普萘洛尔组、激光组和普萘洛尔联合激光组,每组20例。普萘洛尔联合激光组患儿采用普萘洛尔1.5 mg·kg^-1·d^-1联合激光治疗,普萘洛尔组患儿采用普萘洛尔1.5 mg·kg^-1·d^-1,激光组患儿单纯采用激光治疗,比较3组患者治疗6个月后的总有效率、显效率、痊愈率和不良反应程度评分。结果: 治疗6个月后,普萘洛尔联合激光组患儿总有效率、显效率和痊愈率高于激光组和普萘洛尔组(P<0.05),普萘洛尔联合激光组皮肤不良反应程度评分低于激光组和普萘洛尔组(P<0.05)。结论:低剂量普萘洛尔联合1 064 nmNd:YAG激光是治疗混合型和深层IH的一种安全有效的方法,具有疗效好、疗程短和不良反应少的优势。

关键词: 婴儿血管瘤, 普萘洛尔, 1 064 nmNd:YAG激光

Abstract:

Objective To explore the efficacy and safty of low dose propranolol with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma(IH). Methods 60 patients with mixed and deeper IH were randomly divided into propranolol group(n=20,the patients were treated by 1.5 mg·kg-1·d^-1 propranolol),laser group(n=20,the patients were treated by 1 064 nm Nd:YAG laser), and propranolol combined with laser group(n=20,the patients were treated by 1.5 mg·kg^-1·d^-1 propranolol and 1 064 nm Nd:YAG laser).After 6 months,the total efficacy rate, efficacy rate and cure rate,and the scores of adverse event degrees were compared respectively. Results 6 months later,the total efficacy rate,efficacy rate and cure rate of the patients in propranolol combined with laser group were higher than those in laser group and propranolol group(P<0.05);the scores of adverse event degrees in body surface of the patients in propranolol combined with laser group were lower than those in laser group and propranolol group(P<0.05). Conclusion Low dose of propranolol combined with 1 064 nm Nd:YAG laser is effective and safe for the patients with mixed and deeper IH,with the advantages such as better effects,shorter duration and fewer adverse events.

Key words: infantile hemangioma, propranolol, 1 064 nm Nd:YAG laser

中图分类号:

R732.2

钟淑霞, 陶育纯, 周俊峰, 姚蕾, 刘媛媛, 闫冬雪, 李珊山. 低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价[J]. 吉林大学学报(医学版), 2015, 41(05): 1032-1035.

ZHONG Shuxia, TAO Yuchun, ZHOU Junfeng, YAO Lei, LIU Yuanyuan, YAN Dongxue, LI Shanshan. Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma[J]. Journal of Jilin University Medicine Edition, 2015, 41(05): 1032-1035.

参考文献

[1] Waner M,Suen JY.Management of congenital vascular lesions of the head and neck[J].Oncology (Williston Park),1995,9(10):989-994,997.

[2] Chang LC,Haggstrom AN,Drolet BA,et al.Growth characteristics of infantile hemangiomas:implications for management[J].Pediatrics,2008,122(2):360-367.

[3] Jacobs AH.Strawberry hemangiomas;the natural history of the untreated lesion[J].Calif Med,1957,86(1):8-10.

[4] Zheng JW,Zhang L,Zhou Q,et al.A practical guide to treatment of infantile hemangiomas of the head and neck[J].Int J Clin Exp Med,2013,6(10):851-860.

[5] Raulin C,Greve B.Retrospective clinical comparison of hemangioma treatment by flashlamp-pumped (585 nm) and frequency-doubled Nd:YAG (532 nm) lasers[J].Lasers Surg Med,2001,28(1):40-43.

[6] 谭明,段波,周春梅,等.普萘联合1064nmNd:YAG激光治疗体表增殖期血管瘤的临床观察[J].中华整形外科杂志,2012,28(3):164-168.

[7] Bagazgoitia L,Hernandez-Martin A,Torrelo A.Recurrence of infantile hemangiomas treated with propranolol[J].Pediatr Dermatol,2011,28(6):658-662.

[8] Naouri M,Schill T,M aruani A,et al.Successful treatment of ulcerated haemangioma with propranolol[J].J Eur Acad Dermatol Venereol,2010,24(9):1109-1112.

[9] Holmes WJ,Mishra A,Gorst C,et al.Propranolol as first-line tretment for infantile haemangiomas[J].Plast Reconstr Surg,2010,125(1):420-421.

[10] Lawley LP,Siegfried E,Todd JL.Propranolol treatment for hemangioma of infancy:risk and recommendations[J].Pediatr Dermatol,2009,26(5):610-614.

[11] 秦中平,刘学键,李克雷,等.小剂量普奈洛尔口服治疗婴儿血管瘤的近期疗效与安全性评价[J].中华医学杂志,2009,89(44):3130-3134.

[12] Chun SH,Park DH,Jung HL,et al.Successful and safe treatment of hemangioma with oral propranolol in a single institution[J].Korean J Pediatr,2012,55(5):164-170.

[13] 杨舟,李丽,徐子刚,等.普奈洛尔治疗婴儿血管瘤的临床疗效及安全性[J].中华皮肤科杂志,2012,45(7):466-469.

[14] 钟淑霞,陶育纯,周俊峰,等.不同剂量普奈洛尔治疗婴儿血管瘤的疗效评价[J].吉林大学学报:医学版,2014,40(4):880-883.

低剂量普萘洛尔联合1064nmNd:YAG激光治疗混合型和深层婴儿血管瘤的疗效评价

Evaluation on efficacy of low dose propranololcombined with 1 064 nm Nd:YAG laser on mixed and deeper infantile hemangioma

RichHTML

PDF (PC)

赞

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 1

Metrics

本文评价

推荐阅读 0