吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (01): 125-129.doi: 10.13481/j.1671-587x.20170125

• 临床医学 • 上一篇    下一篇

枸橼酸莫沙必利治疗帕金森综合征患者消化道功能紊乱的疗效

刘洋1, 刘志2, 李凤娥3, 孔繁利1   

  1. 1. 北华大学基础医学院病理生理学教研室, 吉林 吉林 132013;
    2. 吉林省吉林市中心医院神经科, 吉林 吉林 132011;
    3. 北华大学附属医院神经二科, 吉林 吉林 132013
  • 收稿日期:2016-05-03 出版日期:2017-01-28 发布日期:2017-02-08
  • 通讯作者: 孔繁利,副教授,硕士研究生导师(Tel:0432-64608018,E-mail:kongfanli5@163.com);刘志,副教授(Tel:0432-63073089,E-mail:lzsky7@outlook.com) E-mail:kongfanli5@163.com;lzsky7@outlook.com
  • 作者简介:刘洋(1975-),女,吉林省吉林市人,讲师,医学博士,主要从事超声及神经变性疾病方面的研究。
  • 基金资助:

    吉林省教育厅科研基金资助课题(2015-164,2013-162,2013-315)

Therapeutic effect of mosapride citrate on gastrointestinal tract function disorder of patients with Parkinson's syndrome

LIU Yang1, LIU Zhi2, LI Fenge3, KONG Fanli1   

  1. 1. Department of Pathophysiology, School of Basic Medical Sciences, Beihua University, Jilin 132013, China;
    2. Department of Neurology, Center Hospital of Jilin City, Jilin Province, Jilin 132011, China;
    3. Second Department of Neurology, Affiliated Hospital, Beihua University, Jilin 132013, China
  • Received:2016-05-03 Online:2017-01-28 Published:2017-02-08

摘要:

目的:探讨枸橼酸莫沙必利对帕金森综合征患者下消化道功能紊乱的治疗作用,阐明其作用机制。方法:选择伴有消化道功能紊乱的帕金森综合征患者29例,其中男性19例,女性10例,平均年龄68.7岁,每日给予枸橼酸莫沙必利15 mg,分3次口服,连续3个月。测定患者结肠通过时间(CTT),行结直肠造影测定患者不同阶段直肠内压力和容量。结果:经枸橼酸莫沙必利治疗后,所有患者排便困难均好转。与治疗前比较,枸橼酸莫沙必利治疗后患者平均CTT缩短(P<0.05),尤其是左半部CTT缩短明显(P<0.01);与治疗前比较,枸橼酸莫沙必利治疗后,在直肠充盈的过程中,初发便意明显降低(P<0.05)。结论:枸橼酸莫沙必利作为一种新型5-HT4受体兴奋剂及5-HT3受体拮抗剂,对帕金森综合征患者具有促进结直肠蠕动及通便的作用。

关键词: 枸橼酸莫沙必利, 下消化道功能紊乱, 帕金森综合征

Abstract:

Objective: To explore the therapeutic effect of mosapride citrate on lower gastrointestinal tract function disorder of the patients with Parkinson's syndrome, and to clarify its mechnism.Methods: A total of 29 patients with Parkinson's syndrome complicated with lower gastrointestinal tract function disorder (20 men,9 women; mean age, 68.7 years) were selected and treated with 15 mg of mosapride citrate 3 times a day,by oral for 3 months. The colonic transit time (CTT) of the patients was detected.and rectoanal videomanometry was used to measure the pressures and capacities in colon of the patients at different periods.Results: The defecation diffculties were improved after treated with mosapride citrate. Compared with before treatment, the mean CTT of the patients after treatment was shorten (P<0.05), expecially in the left colon (P<0.01). Compared with before treatment, mosapride augmented the amplitude in rectal contraction after treatment (P<0.05) and lessened the volume of postdefecation residuals.Conclusion: As a kind of 5-HT4 receptor agonist and 5-HT3 receptor antagonistic agent, mosapride citrate can promote the lower gastrointestinal tract motility and ameliorate constipation in the Parkinson's syndrome patients.

Key words: lower gastrointestinal tract disorder, mosapride citrate, Parkinson's syndrome

中图分类号: 

  • R574.4