牛奶蛋白过敏婴幼儿常见过敏原sIgE阳性率分析

doi:10.13481/j.1671-587x.20180228

吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (02): 363-367.doi: 10.13481/j.1671-587x.20180228

牛奶蛋白过敏婴幼儿常见过敏原sIgE阳性率分析

柯海劲, 陈小燕, 郭勇, 罗丽辉, 吴婕翎

广东省妇幼保健院儿童保健科, 广东广州 511400

收稿日期:2017-10-10 出版日期:2018-03-28 发布日期:2018-03-30
通讯作者: 吴婕翎,主任医师(Tel:020-39151521,E-mail:jieling101@189.cn) E-mail:jieling101@189.cn
作者简介:柯海劲(1971-),女,广东省广州市人,副主任医师,主要从事儿童保健临床及科研方面的研究。
基金资助:
广东省卫计委医学科研基金资助课题（A2013081）；中国疾病预防控制中心妇幼保健中心科研基金资助课题（2014FY004）

Analysis of positive rate of sIgE for common allergens in infants with cow'smilk protein allergy

KE Haijin, CHEN Xiaoyan, GUO Yong, LUO Lihui, WU Jieling

Department of Child Health, Guangdong Women and Children's Hospital, Guangzhou 511400, China

Received:2017-10-10 Online:2018-03-28 Published:2018-03-30

摘要/Abstract

摘要： 目的：探讨牛奶蛋白过敏（CMPA）和健康婴幼儿常见过敏原特异性免疫球蛋白E （sIgE）的阳性率差异，明确CMPA婴幼儿常见过敏原sIgE阳性分布特征，为CMPA患儿综合干预提供依据。方法：选择156例CMPA （CMPA组）和318名健康婴幼儿（健康组）作为研究对象，采用酶联免疫吸附法检测2组婴幼儿血清中常见过敏原sIgE和总IgE水平，比较2组婴幼儿常见过敏原sIgE和总IgE阳性率差异。结果：CMPA组和健康组婴幼儿常见过敏原sIgE和总IgE的阳性率比较差异无统计学意义（P>0.05）；CMPA组sIgE阳性率较高的食物过敏原为牛奶（44.2%）、鸡蛋白（10.3%）和腰果（5.1%），sIgE阳性率较高的吸入性过敏原为猫毛皮屑（21.2%）、狗毛皮屑（9.6%）和户尘螨（4.5%）；健康组sIgE阳性率较高的食物过敏原为牛奶（45.0%）、鸡蛋白（14.2%）和腰果（6.0%），sIgE阳性率较高的吸入性过敏原为猫毛皮屑（25.8%）、狗毛皮屑（14.5%）和真菌组合（4.5%）。不同年龄段（<1岁与1~2岁）分组分析，CMPA组和健康组婴幼儿常见过敏原sIgE阳性率比较差异无统计学意义（P>0.05）。结论：CMPA和健康婴幼儿常见过敏原血清sIgE阳性率未发现明显差异，提示CMPA婴幼儿行血清sIgE检测的临床指导意义证据尚显不足。

关键词: 特异性免疫球蛋白E, 牛奶蛋白过敏, 酶联免疫吸附法, 过敏原, 婴幼儿

Abstract: Objective:To explore the differences in the positive rates of specific-IgE(sIgE) of the common allergens between the cow's milk protein allergy (CMPA) and healthy infants and the distribution characteristics of positive sIgE of common allergens in the CMPA infants,and to provide basis for comprehensive intervention of the CMPA infants. Methods: A total of 156 cases of CMPA and 318 cases of healthy infants were selected as the subjects. The serum sIgE and total IgE levels of common allergens of the infants in two groups were detected by enzyme-linked immunosorbent assay. The differences in the positive rates of serum sIgE of common allergens and total IgE of the infants in two groups were compared. Results: There were no statistical differences in the positive rates of serum sIgE and total IgE for common allergens of the infants between CMPA group and healthy group(P>0.05).The major food allergens with high positive rates of sIgE in CMPA group were cow's milk(44.2%),egg white(10.3%) and cashew nut(5.1%), and the inhale allergens with high positive rates of sIgE were cat hair(21.2%), dog hair(9.6%) and house dust mite(4.5%).While for the healthy infants, the major food allergens with high positive rates of sIgE were cow's milk(45%),egg white (14.2%)and cashew nut(6.0%),and the inhale allergens with high positive rates of sIgE were cat hair(25.8%),dog hair(14.5%)and fungus combinations(4.5%). The analysis in different age groups (<1 year old and 1-2 years old) showed that there were no statistical differences in the positive rates of serum sIgE and total IgE for common allergens of the infants between CMPA group and healthy group(P>0.05). Conclusion: There are no significant differences in the serum sIgE and total IgE positive rates between the CMPA and healthy infants. The detection of serum sIgE and total IgE of common allergens is of little clinical significance for the CMPA infants.

Key words: cow's milk protein allergy, allergen, sIgE, enzymelinked immunosorbent assay, infant

中图分类号:

R446.11

柯海劲, 陈小燕, 郭勇, 罗丽辉, 吴婕翎. 牛奶蛋白过敏婴幼儿常见过敏原sIgE阳性率分析[J]. 吉林大学学报(医学版), 2018, 44(02): 363-367.

KE Haijin, CHEN Xiaoyan, GUO Yong, LUO Lihui, WU Jieling. Analysis of positive rate of sIgE for common allergens in infants with cow'smilk protein allergy[J]. Journal of Jilin University Medicine Edition, 2018, 44(02): 363-367.

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牛奶蛋白过敏婴幼儿常见过敏原sIgE阳性率分析

Analysis of positive rate of sIgE for common allergens in infants with cow'smilk protein allergy

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