吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (03): 579-584.doi: 10.13481/j.1671-587x.20180323

• 临床研究 • 上一篇    下一篇

中间型血友病患者四肢主要关节功能状况分析

马乐1,2, 范猛2, 薛峰3, 姜文学2   

  1. 1. 天津医科大学一中心临床学院骨科, 天津 300070;
    2. 天津市第一中心医院骨科, 天津 300192;
    3. 中国医学科学院北京协和医学院血液学研究所血液病医院骨科, 天津 300020
  • 收稿日期:2017-12-27 出版日期:2018-05-28 发布日期:2018-05-31
  • 通讯作者: 姜文学,主任医师,硕士研究生导师(Tel:020-23626353,E-mail:jiangwenxue1920@163.com) E-mail:jiangwenxue1920@163.com
  • 作者简介:马乐(1990-),男,吉林省延吉市人,在读医学硕士,主要从事骨关节炎诊治方面的研究。
  • 基金资助:
    天津市卫计委公关项目资助课题(16KG102)

Analysis on functional status of major joints in limbs of moderate hemophilia patients

MA Le1,2, FAN Meng2, XUE Feng3, JIANG Wenxue2   

  1. 1. Department of Orthopedics, First Central Clinical College, Tianjin Medical University, Tianjin 300070, China;
    2. Department of Orthopedics, Tianjin First Central Hospital, Tianjin 300192, China;
    3. Department of Orthopedics, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China
  • Received:2017-12-27 Online:2018-05-28 Published:2018-05-31

摘要: 目的:分析93例血友病患者四肢主要关节功能状况,提高对该病的认识和管理。方法:93例中间型(FVⅢ:C/FⅨ:C1%~5%)血友病患者根据患者年龄分为7个亚组,即<10岁组,10~20岁组,20~30岁组,30~40岁组,40~50岁组,50~60岁组,>60岁组。统计患者各关节血友病性关节炎累及率,采用血友病关节健康评分(HJHS)评估患者四肢主要关节功能状况。结果:中间型和重型血友病患者各关节累及率比较差异均无统计学意义(P>0.05)。中间型血友病患者平均HJHS与重型血友病患者比较差异无统计学意义(P=0.157)。20~30岁重型血友病患者平均HJHS高于中间型血友病患者(Z=-2.127,P=0.033)。10~20岁组和20~30岁组中间型和重型血友病患者膝关节HJHS比较差异有统计学意义(Z10~20=-2.710,P10~20=0.007;Z20~30=-2.384,P20~30=0.017),其他各个年龄段中间型和重型血友病患者HJHS比较差异无统计学意义(P>0.05)。结论:中间型血友病患者出血治疗现状较差,采取按需治疗和预防治疗相结合的方法可有效减少关节出血,有效保证血友病患者关节功能,提高患者生活质量。

关键词: 按需治疗, 中间型血友病, 血友病性关节炎, 血友病

Abstract: Objective: To detect the functional status of major joints in limbs of the patients with moderate hemophilia,and to improve the understanding and management of hemophilia. Methods: A total of 93 patients with moderate hemophilia (FVⅢ:C/FⅨ:C:1%-5%) were divided into seven subgroups according to their ages:<10 years,10-20 years,20-30 years,30-40 years,40-50 years,50-60 years,and > 60 years. The joint involvement rates of patients were observed and the joint function was evaluated using Hemophilia Joint Heath Score (HJHS). Results: Compared with moderate hemophilia group,the difference in the involvement rate of hemophilic arthritis of the patients in severe hemophilia group was not significant(P>0.05).The mean HJHS of the patients in moderate hemophilia group and severe hemophilia group had no statistical difference (P=0.157).In 20-30 years group,the mean HJHS of the patients in severe hemophilia group was higher than that in moderate hemophilia group(Z=-2.127,P=0.033). In 10-20 years and 20-30 years groups,there were statistically significant differences in the HJHS of knee joint between moderate hemophilia group and severe hemophilia group(Z10-20=-2.710,P10-20=0.007;Z20-30=-2.384,P20-30=0.017).There were no significant differences in the HJHS of the patients in moderate hemophilia group and severe hemophilia group at the different ages (P>0.05). Conclusion: The hemorrhage treatment status of moderate hemophilia patients is poor.The combination of on-demand treatment and preventive treatment can reduce the joint hemorrhage,and guarantee the joint function of hemophilia patients effectively and improve the life quality of the patients.

Key words: on-demand treatment, hemophilia, hemophilic arthritis, moderate hemophilia

中图分类号: 

  • R684.2