IL-17E和IL-17F及其受体在结直肠癌组织中的表达及其意义

doi:10.13481/j.1671-587x.20180322

吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (03): 574-578.doi: 10.13481/j.1671-587x.20180322

IL-17E和IL-17F及其受体在结直肠癌组织中的表达及其意义

杨学良¹, 孙雪梅^2,3, 赵晓晖², 杨丽娟², 沈维高⁴, 肖梓屾², 郭冲², 刘艳波²

1. 北华大学附属医院普外科, 吉林吉林 132012;
2. 北华大学基础医学院病理生理学教研室, 吉林吉林 132013;
3. 吉林省东丰县中医院急诊科, 吉林东丰 136300;
4. 吉林医药学院附属医院外科, 吉林吉林 132011

收稿日期:2017-09-02 出版日期:2018-05-28 发布日期:2018-05-31
通讯作者: 刘艳波,教授,硕士研究生导师(Tel:0432-64608106,E-mail:liuyanbobeihua@163.com) E-mail:liuyanbobeihua@163.com
作者简介:杨学良(1974-),男,吉林省吉林市人,副主任医师,主要从事消化道恶性肿瘤防治方面的研究。
基金资助:
国家自然科学基金资助课题（81302226）；吉林省科技厅科研基金资助课题（20130101164JC，20140414059GH）；吉林省教育厅科研基金资助课题（20132070，2014200，2015129）；吉林省卫计委科研基金资助课题（104900496）

Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances

YANG Xueliang¹, SUN Xuemei^2,3, ZHAO Xiaohui², YANG Lijuan², SHEN Weigao⁴, XIAO Zishen², GUO Chong², LIU Yanbo²

1. Department of General Surgery, Affiliated Hospital, Beihua University, Jilin 132012, China;
2. Department of Pathophysiology, College of Basic Medical Sciences, Beihua University, Jilin 132013, China;
3. Department of Emergency, Traditional Chinese Medicine Hospital, Dongfeng County, Dongfeng 136300, China;
4. Department of Surgery, Affiliated Hospital, Jilin Medical College, Jilin 132013, China

Received:2017-09-02 Online:2018-05-28 Published:2018-05-31

摘要/Abstract

摘要： 目的：观察配体白细胞介素17E（IL-17E）、白细胞介素17F（IL-17F）及其受体白细胞介素17RB（IL-17RB）和白细胞介素17RC（IL-17RC）在肠炎、肠息肉及结直肠癌组织中的表达，探讨其与直结肠癌恶性度的关系。方法：收集15例肠炎、5例增生性肠息肉及30例结直肠腺癌组织病理标本，采用免疫组织化学染色法检测IL-17E、IL-17RB、IL-17F和IL-17RC在肠炎、肠息肉和肠癌组织中的阳性表达率，分析配体与受体阳性表达率的相关性以及配体阳性表达率与肠癌恶性度的关联。结果：IL-17E、IL-17F、IL-17RB和IL-17RC主要表达于腺上皮细胞、单个核细胞、血管内皮细胞和部分癌细胞；IL-17E在肠炎和肠息肉组织中的阳性表达率明显高于肠癌组织（P<0.05），且随肠癌恶性度升高而降低；IL-17F在肠息肉和肠癌组织中阳性表达率明显高于肠炎组织（P<0.05），且随肠癌恶性度的升高而升高；IL-17RB在肠炎及息肉组织中的阳性表达率明显高于肠癌组织（P<0.05）。与肠炎和肠息肉比较，肠癌组织中IL-17RC阳性表达率升高（P<0.05）。在肠癌组织中，IL-17F阳性表达率与IL-17RC阳性表达率呈正相关关系（r=0.667，P=0.001）。结论：IL-17F、IL-17RC、IL-17E和IL-17RB信号可能参与了肠癌的发生发展。

关键词: 白细胞介素17RC, 肠肿瘤, 白细胞介素17E, 白细胞介素17F, 白细胞介素17RB

Abstract: Objective: To explore the expressions of interleukin-17E(IL-17E),interleukin -17F(IL-17F) and their receptors interleukin -17RB(IL-17RB),interleukin -17RC(IL-17RC) in enteritis,intestinal polyps and colorectal carcinoma tissues,and to analyze their relationships with the malignancy of colorectal carcinoma. Methods: Immunohistochemistry staining was used to detect the expressions of IL-17E,IL-17RB,IL-17F, and IL-17RC in the tissues of enteritis (n=15),intestinal polyps (n=5) and colorectal carcinoma (n=30).The relationships between IL-17E and IL-17RB,IL-17F and IL-17RC,and the relationships between IL-17E,IL-17F and malignancy of colorectal carcinoma were analyzed. Results: IL-17E,IL-17F,IL-17RB and IL-17RC mainly expressed in glandular epithelial cells,mononuclear cells and vascular endothelial cells as well as partial carcinoma cells.The positive expression rates of IL-17E in enteritis and intestinal polyps tissues were higher than that in colorectal carcinoma tissue (P<0.05).Compared with enteritis tissue,the positive expression rates of IL-17F in intestinal polyps and colorectal carcinoma tissues were increased (P<0.05),which was increased with the increasing of malignancy of coloretal carcinoma.Compared with colorectal carcinoma tissue,the positive expression rates of IL-17RB in enteritis and intestinal polyps tissues were increased (P<0.05).Compared with enteritis and intestinal polyps tissues,the positive expression rate of IL-17RC in colorectal carcinoma tissue was increased (P<0.05).There was positive correlation between the positive expression rate of IL-17F and the positive expression rate of IL-17RC in colorectal carcinoma tissue(r=0.667,P=0.001). Conclusion: IL-17F,IL-17RC,IL-17E,and IL-17RB signals may take part in the incidence and progression of colorectal carcinoma.

Key words: colonrectal neoplasms, interleukin-17E, interleukin -17RC, interleukin -17RB, interleukin -17F

中图分类号:

R735.35

杨学良, 孙雪梅, 赵晓晖, 杨丽娟, 沈维高, 肖梓屾, 郭冲, 刘艳波. IL-17E和IL-17F及其受体在结直肠癌组织中的表达及其意义[J]. 吉林大学学报(医学版), 2018, 44(03): 574-578.

YANG Xueliang, SUN Xuemei, ZHAO Xiaohui, YANG Lijuan, SHEN Weigao, XIAO Zishen, GUO Chong, LIU Yanbo. Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances[J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 574-578.

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IL-17E和IL-17F及其受体在结直肠癌组织中的表达及其意义

Expressions of IL-17E, IL-17F and their receptors in colorectal carcinoma tissue and their significances

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