吉林大学学报(医学版) ›› 2019, Vol. 45 ›› Issue (03): 688-691.doi: 10.13481/j.1671-587x.20190337

• 临床医学 • 上一篇    

子宫内膜去分化癌患者的临床诊治和预后分析(附12例报告)

雷青艳, 王玲, 王博蔚, 张炜旸   

  1. 吉林大学第二医院妇产科, 吉林 长春 130041
  • 收稿日期:2018-09-12 发布日期:2019-06-05
  • 通讯作者: 王博蔚,副教授,硕士研究生导师(Tel:0431-81137036,E-mail:wangbowei2009@hotmail.com);张炜旸,教授,主任医师,硕士研究生导师(Tel:0431-81136867,E-mail:1145651310@qq.com) E-mail:wangbowei2009@hotmail.com;1145651310@qq.com
  • 作者简介:雷青艳(1991-),女,河南省驻马店市人,在读医学硕士,主要从事妇科肿瘤诊治方面的研究。
  • 基金资助:
    吉林省科技厅重点科技研发项目资助课题(20180201056YY)

Clinical diagnosis and prognosis analysis of patients with endometrial dedifferentiated carcinoma: A report of 12 cases

LEI Qingyan, WANG Ling, WANG Bowei, ZHANG Weiyang   

  1. Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041, China
  • Received:2018-09-12 Published:2019-06-05

摘要: 目的:分析子宫内膜去分化癌患者的临床诊治和预后,为其诊治提供依据。方法:回顾性分析12例子宫内膜去分化癌患者的一般资料、辅助检查、治疗方法和病理特征,结合文献复习探讨其诊治方法。结果:12例子宫内膜去分化癌患者中,5例临床晚期患者均死亡,平均生存期为10个月;其余7例临床早期患者均无瘤生存至今,平均生存期为43个月。12例患者均行全子宫切除术+双侧附件切除术+盆腔淋巴结清扫术,其中2例患者加行大网膜和阑尾切除术,平均生存期为8个月;10例患者未切除大网膜和阑尾,平均生存期为24个月。12例患者中,10例患者进行放疗或化疗,平均生存期为32个月;2例患者未行放疗或化疗,平均生存期为16个月。结论:临床晚期子宫内膜去分化癌患者的生存期比临床早期患者短且预后差。未进行放疗或化疗患者的生存期较进行放疗或化疗患者短且预后差。病灶侵及大网膜或阑尾时,大网膜切除术和阑尾切除术是子宫内膜去分化癌的常规手术方式,切除大网膜或阑尾对患者生存期可能无明显影响。

关键词: 子宫肿瘤, 子宫内膜, 去分化癌, 大网膜切除术, 阑尾切除术

Abstract: Objective:To analyze the clinical diagnosis and treatment and prognosis of the patients with endometrial dedifferentiated carcinoma, and to provide the evidence for its diagnosis and treatment. Methods:The general data, auxiliary examinations,treatment methods and pathological features of 12 patients with endometrial dedifferentiated carcinoma were analyzed retrospectively;literature review was performed,and its diagnosis and treatment methods were analyzed. Results:Among the 12 patients with endometrial dedifferentiated carcinoma, 5 patients in late clinical stage all died, and the average survival time was 10 months;the remaining 7 patients in early clinical stage got a disease-free survival time of 43 months.Twelve patients underwent total hysterectomy, bilateral accessory resection and pelvic lymphadenectomy, of which 2 patients underwent omentectomy and appendectomy, with an average survival time of 8 months; a total of 10 patients remained the omentum majus and appendix, with an average survival time of 24 months.Of the 12 patients, a total of 10 patients received radiotherapy or chemotherapy with an average survival time of 32 months, and 2 patients did not receive the radiotherapy or chemotherapy with an average survival time of 16 months. Conclusion:The patients with endometrial dedifferentiation carcinoma in late clinical stage have shorter survival time and worse prognosis than the patients in early clinical stage.The survival time of patients without chemotherapy or radiotherapy is shorter and the prognosis is worse than those of the patients with chemotherapy or radiotherapy.When the lesion invades omentum majus or appendix,omentectomy and appendectomy are the routine surgical methods for endometrial dedifferentiated carcinoma; resection of the omentum majus or appendix may have no significant effect on the survival time of patient.

Key words: uterine neoplasms, endometrium, dedifferentiated carcinoma, omentectomy, appendicectomy

中图分类号: 

  • R737.33