关键词: 实验性, 糖尿病肾病, 胡芦巴, 药理学, 大鼠, Wistar

Abstract: Objective To study the protective effects of fenugreek seeds components A, B on renal lesion in diabetic rats.Methods The model of diabetes mellitus was built with streptozotocin (STZ) in rats. All the rats were randomly divided into four groups: diabetes control group (D) (n=8), fenugreek seeds components A treatment group (A) (n=10), fenugreek seeds components B treatment group (B) (n=10), and normal control group (C) (n=6). Diabetic rats were treated with fenugreek seeds components A,B for 12 weeks, The metabolism levels of blood glucose, blood lipids were determined. Kidney morphology was observed to evaluate the protective effects of fenugreek seeds components A, B on renal structure and function in diabetic rats.Results In diabetic rats treated with fenugreek seeds component s A and B , the levels of blood glucose, urinary protein excretion, serum creatinine, blood urea nitrogen, kidney index and glomerular volume were significantly lower than those in group D (P>0.05，P<0.01). In group A, the levels of TG, LDLC were lighter than those in group D (P>0.05), HDLC was higher than that in group D (P<0.01),CHO had no significant difference with group D. In group B, the levels of TG, LDLC and CHO were lighter than those in group D, whereas the level of HDLC was higher than that in group D (P<0.01). Optical and electromicroscopic findings indicated that the lesions of glomerular of rats in group B were alleviated significantly, and the glomerular structure in group B was better than that in group A. Conclusion Fenugreek seeds components A, B can modulate the metabolism of blood glucose, blood lipids in diabetic rats. Functional and morphological abnormalities in kidney have been lightened. Fenugreek seeds component s may protect the kidney of diabetic rats to a certain degree. The protective effect of components B is better than that of components A.

Key words: experimental, diabetes nephropathy, trigonella foenumgraecum, pharmacology, rats, Wistar