[1] Simon SF,Taylor CG. Dietary zinc supplementation attenuates hyperglycemia in db/db mice[J].Exp Biol Med (Maywood),2001,226(1):43-51. [2] Dinkova-Kostova AT,Holtzclaw WD,Wakabayashi N.Keap1,the sensor for electrophiles and oxidants that regulates the phase 2 response,is a zinc metalloprotein[J].Biochemistry,2005,44(18):6889-6899. [3] Prasad AS.Clinical,immunological,anti-inflammatory and antioxidant roles of zinc[J].Exp Gerontol,2008,43(5):370-377. [4] Zhang X,Liang D,Lian X,et al.Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy[J].Mol Med Rep,2016,14(6):5245-5252. [5] Mapar MA,Pazyar N,Siahpoosh A,et al.Comparison of the efficacy and safety of zinc sulfate vs.placebo in the treatment of pruritus of hemodialytic patients:a pilot randomized,triple-blind study[J].G Ital Dermatol Venereol,2015,150(4):351-355. [6] Mak RH,Cheung W,Cone RD,et al.Leptin and inflammation-associated cachexia in chronic kidney disease[J].Kidney Int,2006,69(5):794-797. [7] Tapiero H,Tew KD.Trace elements in human physiology and pathology:zinc and metallothioneins[J].Biomed Pharmacother,2003,57(9):399-411. [8] Miao X,Sun W,Miao L,et al.Zinc and diabetic retinopathy[J].J Diabetes Res,2013,2013:425854. [9] Capdor J,Foster M,Petocz P,et al.Zinc and glycemic control:a Meta-analysis of randomised placebo controlled supplementation trials in humans[J].J Trace Elem Med Biol,2013,27(2):137-142. [10] Gammoh NZ,Rink L.Zinc in infection and inflammation[J].Nutrients,2017,9(6):624. [11] Kimura T,Kambe T.The functions of metallothionein and ZIP and ZnT transporters:An overview and perspective[J].Int J Mol Sci,2016,17(3):336. [12] Jurowski K,Szewczyk B,Nowak G,et al.Biological consequences of zinc deficiency in the pathomechanisms of selected diseases[J].J Biol Inorg Chem,2014,19(7):1069-1079. [13] Wenzlau JM,Juhl K,Yu L,et al.The cation efflux transporter ZnT8(Slc30A8) is a major autoantigen in human type 1 diabetes[J].Proc Natl Acad Sci USA,2007,104(43):17040-17045. [14] Shiroi A,Yoshikawa M,Yokota H,et al.Identification of insulin-producing cells derived from embryonic stem cells by zinc-chelating dithizone[J].Stem Cells,2002,20(4):284-292. [15] Taniguchi M,Enomoto S,Hiromura M.The regulation of the activation in BCR signaling by ZIP9 transporter[J].Yakugaku Zasshi,2014,134(7):809-812. [16] Quraishi I,Collins S,Pestaner JP,et al.Role of zinc and zinc transporters in the molecular pathogenesis of diabetes mellitus[J].Med Hypotheses,2005,65(5):887-892. [17] Prasad AS.Zinc:an antioxidant and anti-inflammatory agent:role of zinc in degenerative disorders of aging[J].J Trace Elem Med Biol,2014,28(4):364-371. [18] Yang F,Li B,Dong X,et al.The beneficial effects of zinc on diabetes-induced kidney damage in murine rodent model of type 1 diabetes mellitus[J].J Trace Elem Med Biol,2017,42(7):1-10. [19] Barman S,Srinivasan K.Attenuation of oxidative stress and cardioprotective effects of zinc supplementation in experimental diabetic rats[J].Br J Nutr,2017,117(3):335-350. [20] Jansen J,Karges W,Rink L.Zinc and diabetes-clinical links and molecular mechanisms[J].J Nutr Biochem,2009,20(6):399-417. [21] Khan MI,Siddique KU,Ashfaq F,et al.Effect of high-dose zinc supplementation with oral hypoglycemic agents on glycemic control and inflammation in type-2 diabetic nephropathy patients[J].J Nat Sci Biol Med,2013,4(2):336-340. [22] Luo YY,Zhao J,Han XY,et al.Relationship between serum zinc level and microvascular complications in patients with type 2 diabetes[J].Chin Med J,2015,128(24):3276-3282. [23] Parham M,Amini M,Aminorroaya A,et al.Effect of zinc supplementation on microalbuminuria in patients with type 2 diabetes:a double blind,randomized,placebo-controlled,cross-over trial[J].Rev Diabet Stud,2008,5(2):102-109. [24] Sun W,Wang Y,Miao X,et al.Renal improvement by zinc in diabetic mice is associated with glucose metabolism signaling mediated by metallothionein and Akt,but not Akt2[J].Free Radic Biol Med,2014,68:22-34. [25] Foster M,Samman S.Zinc and redox signaling:perturbations associated with cardiovascular disease and diabetes mellitus[J].Antioxid Redox Signal,2010,13(10):1549-1573. [26] Takahashi M,Saito H,Higashimoto M,et al.Possible inhibitory effect of oral zinc supplementation on hepatic fibrosis through downregulation of TIMP-1:A pilot study[J].Hepatol Res,2007,37(6):405-409. [27] Zhang X,Liang D,Fan J,et al.Zinc attenuates tubulointerstitial fibrosis in diabetic nephropathy via inhibition of HIF through PI-3K signaling[J].Biol Trace Elem Res,2016,173(2):372-383. [28] Tang Y,Yang Q,Lu J,et al.Zinc supplementation partially prevents renal pathological changes in diabetic rats[J].J Nutr Biochem,2010,21(3):237-246. [29] Li F,Cong T,Li Z,et al.Effects of zinc deficiency on the relevant immune function in rats with sepsis induced by endotoxin/lipopolysaccharide[J].Zhonghua Shao Shang Za Zhi,2015,31(5):361-366. [30] Kurihara N,Yanagisawa H,Sato M,et al.Increased renal vascular resistance in zinc-deficient rats:role of nitric oxide and superoxide[J].Clin Exp Pharmacol Physiol,2002,29(12):1096-1104. [31] Brieger A,Rink L,Haase H.Differential regulation of TLR-dependent MyD88 and TRIF signaling pathways by free zinc ions[J].J Immunol,2013,191(4):1808-1817. [32] Maiguma YM,Suzuki Y,Suzuki H,et al.Dietary zinc is a key environmental modifier in the progression of IgA nephropathy[J].PLoS One,2014,9(2):e90558. [33] Uwaezuoke SN.Steroid-sensitive nephrotic syndrome in children:triggers of relapse and evolving hypotheses on pathogenesis[J].Ital J Pediatr,2015,41:19. [34] Arun S,Bhatnagar S,Menon S,et al.Efficacy of zinc supplements in reducing relapses in steroid-sensitive nephrotic syndrome[J].Pediatr Nephrol,2009,24(8):1583-1586. [35] Sherali AR,Moorani KN,Chishty SH,et al.Zinc supplement in reduction of relapses in children with steroid sensitive nephrotic syndrome[J].J Coll Physicians Surg Pak,2014,24(2):110-113. [36] Aggarwal R,Sentz J,Miller MA.Role of zinc administration in prevention of childhood diarrhea and respiratory illnesses:a meta-analysis[J].Pediatrics,2007,119(6):1120-1130. [37] Roth DE,Richard SA,Black RE.Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries:meta-analysis and meta-regression of randomized trials[J].Int J Epidemiol,2010,39(3):795-808. [38] Sanada S,Kuze M,Yoshida O.Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels[J].Hinyokika Kiyo,1987,33(12):1955-1960. [39] Lobo JC,Aranha LN,Moraes C,et al.Linking zinc and leptin in chronic kidney disease:future directions[J].Biol Trace Elem Res,2012,146(1):1-5. [40] AnubhutiAS.Role of neuropeptides in appetite regulation and obesity--a review[J].Neuropeptides,2006,40(6):375-401. [41] 朱徐慧,丁钢强,章荣华,等.铁、锌、铜、硒、锰与代谢综合征的研究进展[J].中国老年学杂志,2016,36(1):197-200. [42] Ott ES,Shay NF.Zinc deficiency reduces leptin gene expression and leptin secretion in rat adipocytes[J].Exp Biol Med (Maywood),2001,226(9):841-846. |