关键词: 脑缺血, 疾病模型, 动物

Abstract: Objective To study the protective effects of flavone mixture of crataegus leaves（FMCL） on cerebral ischemia. Methods The local cerebral ischemia model was initiated by the middle cerebral artery occlusion （MCAO） in rats for 4 h. The neurologic deficit score and the activities of creatine kinase （CK）， lactata dehydrogenase （LDH）, superoxide （SOD） and the content of serum malondialdehyde （MDA）in MCAO rats were measured. At the same time blood stasis models were built in rats. The effects of FMCL on platelet aggregation，blood viscosity (ηB) and plasma viscosity (ηP) were detected. Results Compared with the model group ,FMCL (60 and 30 mg·kg^-1) increased SOD activity， decreased CK and LDH activities and serum MDA content in a dose dependent manner in MCAO rats （P<0.05）. It could also decrease the neurologic deficit in MCAO rats （P<0.05） . And it could decrease platelet aggregation rate, ηB and ηP （P<0.01，P<0.05）.Conclusion FMCL has protective effects on cerebral ischemia and its mechanism may be related to lowing ηB,ηP and preventing platelet aggregation.

Key words: brain ischemia, disease models, animal