关键词: 乳腺肿瘤, 免疫组织化学

Abstract: Objective To study the expression of 17β-hydroxysteroid dehydrogenase(17β-HSD) type 2 in breast cancer and adjacent non-malignant tissue,and the correlations between the results and clinical factors.Methods The expressions of the oxidative enzyme 17β-HSD type 2 in 76 specimens of female human breast cancer and adjacent non-malignant tissues were determined by immunohistochemistry.The relationships between the clinical parameters including patient’〖KG-*3〗s age, ER,PR,P185,the stage of breast cancer,tumor size and the percentage of involved lymph nodes were analyzed.Results 17β-HSD type 2 was found in the cytoplasm of tumor cells in 5.3% of cases.In adjacent non-malignant tissues,82.9% of cases were positive and the enzyme was detected in the cytoplasm of epithelial cells of the acini and ducts.There was a significant difference between the malignant tissue and the adjacent non-malignant tissue in the percentage of positive cells(χ²=92.908,P<0.001).In adjacent non-malignant tissues,the expression of 17β-HSD type 2 was negatively correlated with the tumor size（r=－0.341，P<0.05），the stage of the breast cancer（r=－0.706，P<0.01） and was positively correlated with the patient's age（r=0.677，P<0.01）. For the other clinical parameters including ER,PR,P185 and the percentage of involved lymph nodes,there was no significant correlation.No significant correlation was found between the expression of 17β-HSD type 2 and all clinical parameters in breast cancer tissue.Conclusion 17β-HSD type 2 can regulate the local estrogen level.It may play a significant role in the development and/or progression of breast cancer.

Key words: breast neoplasms, immunohistochemistry