关键词: 心肌梗塞, 血流动力学, 疾病模型, 动物

Abstract: Objective To study the effects of ginseng fruit saponins(GFS) on hemodynamics in acute myocardial infarction dogs.Methods The acute myocardial infarction models were induced by ligation left anterior descending coronary for 6 h in 30 dogs.GFS was divided into three doses groups(2.5,5.0 and 10.0 mg•kg^-1) and administered with intravenous drip.Pulse-activating injection was taken as positive control medicine and administered with intravenous drip.Infarction model group, normal saline was administered with intravenous drip.After treated with GFS (in dosages of 2.5-10 mg•kg^-1 iv drip )for 90 min,the changes of parameters of heart function and hemodynamics were recorded.Results Compared with model control group,the heart rate (HR) was slowed (P<0.05 or P<0.01); systolic blood pressure (SBP),diastolic blood pressure (DBP),left ventricular systolic pressure (LVSP),maximum left ventricular rise rate (+dp/dt_max) and maximum left ventricular fall rate (－dp/dt_max) and cardiac output (CO) were increased (P<0.05 or P<0.01) ; and left ventricular end-diastolic pressure (LVEDP) was decreased after treated with GFS (in dosages of 5.0 and 10.0 mg•kg^-1 iv drip) for 90 min. Its effect was the same with pulse-activating injection.Conclusion GFS can improve myocardial systolic and diastolic function,and relieve pump failure after myocardial infarction.GFS can also decrease the myocardial volume of oxygen consumption to profit increasing myocardial blood-supply.

Key words: myocardial infarction, hemodynamics, disease model, animal