关键词: 血流动力学, 结缔组织生长因子, 心肌结构

Abstract: Objective To discuss the effect of total arasolides of aralia elata（Miq） seem (TASAES) on cardiac function and protective effect on mgocardial structure in rats with early stage diabetes． Methods The models of diabetic rats were made by an intra-abdominal injection of streptozotocin(STZ)．Rats were divided into control group（C group），model group（M group） and TASAES 4.9,9.8,19.6 mg•kg^-1 groups（T₁，T₂，T₃ groups）．At the time of 8 weeks, the hemodynamic parameters were detected in various groups; ultrastructure of cardiomyocytes was observed under electron microscope；the expression of connective tissue growth factor(CTGF) was detected by RT-PCR technique at the molecular level．Results Compared with model group,TASAES increased the absolute value of left ventricular systolic pressure（LVSP） and ±dp/dt_max in diabetic rats，especially in high and middle dosage groups (P<0.05，P<0.01),it improved the ultrastructure of cardiomyocytes and reduced the expression of CTGF in high and middle dosage groups (P<0.01).Conclusion TASAES can improve the cardiac function　of diabetic rats in a dose dependent manner， and its protective effect may be related to the reduction of CTGF and enhancement of cardiac contractility.

Key words: hemodynamics, connective tissue growth factor, cardiac structure