关键词: 迟发性神经病, 周围神经, 病理学, 电生理学

Abstract: Objective To investigate pathological characteristics of peripheral nerves and muscles and the relationship between these changes and neuroelectrophysiological changes after methamidophos poisoning in hens. Methods Fifty Leghorn hens were divided into 5 groups at random（n=10）. Experimental groups were given methamidophos through a cannula by mouth and were injected atropine sulfate to live through urgent period. The per oneal nerves, gastrocnemius muscles and sciatic nerves were taken at the end of first, second ,third, fouth and eighth week. Morphological study was carried out. Results Mild myelinated fiber abnormalities were found in peroneal nerves at end of second week in experimental group. Nerve fiber degenerat ion, heaven-stained myelin sheath and axonal swelling were occurred at end of the third and fourth week. Fiber necrosis in the gastrocnemius muscles were seen at the third and fourth week. Low amplitude was shown in neuroelectrophysiological examination of sciatic nerves at first week after poisoning. Till the eighth week, motor nerve conduction velocity and terminal latent period renewed to normal. Conclusion Earlier pathological changes can be found by neuroel ectrophysiological examination, while neuropathological changes of peripheral n erves and muscles can be used to judge prognosis.

Key words: delayed neuropathy, neuropathology, peripheral nerves, pathology, electrophysiology