关键词: 抗抑郁药, 白细胞介素2, 白细胞介素6, 皮质醇, 疾病模型, 动物

Abstract: Objective To study the effects of Shugan Jieyuling self-made (SJSM) on behavior, levels of serum IL-2, IL-6 and cortisol in depression model mice. Methods The adult mice separately raised and treated with chron ic unpredictable middle stress stimulus were used to establish depression models. The curative effect of SJSM was observed in depression model mice.The changes of weight and behavior were detected in a period. Radioimmunoassay（RIA） was used to examine the contents of serum IL-2, IL-6 and cortisol levels. Results The increased weights of the depression model mice were declined compared with the normal mice before administration. The mental state and behavior of the depression mice were changed. The mice were starling, dreadful, helpless and immobile. At the same time the contents of serum IL-2, IL-6 and cortisol were obviously lower than those of the normal mice. SJSM (large and low doses) and Baiyoujie changed the increased weights and behaviors of the depression after administration for 21 d. The mental state was meliorated simultaneously，and the serum IL-2, IL-6 and cortisol levels in the depression model mice were decreased significantly compared with normal mice. Conclusion The levels of serum IL-2, IL-6 and cortisol may be the guideline for the diagnosis of depression disease. SJSM can obviously improve both the symptoms of the depression models and the levels of serum IL-2, IL-6 and cortisol.

Key words: antidepressive agents, cortisol, interleukin-2, interleukin-6, disease models, animal