关键词: 毒性, 甲状腺素, 血液, 促甲状腺素, 血液, 胆固醇, 血液

Abstract: Objective To observe the toxic effects of 2-metheyl-4-chlorophenoxyacetic acid (MCPA) on female mice. Methods The different doses of MCPA (20,100, and 200 mg•kg^-1. Weight.p.o) were given to the mice. The weight,the levels of T₄,TSH, and cholesterol in serum, and the organ coefficient of spleen were analyzed. Results In mid-,high-dose groups, the weight of mice and level of TSH in serum had significantly lowered than that in the control and low-dose groups, but the level of cholesterol in serum was significantly increased than that in low-dose and control groups. In the high-dose group, the level of T₄ in blood was reduced significantly compared with control. Conclusion In the experimental conditions, MCPA can obstruct growing, make endocrine function disorder, and decrease the spleen weight of mice.

Key words: toxicity, thyroxine, blood, thyrotropin, blood, cholesterol, blood