人参皂苷拮抗醋酸铅对大鼠胚胎发育毒性的研究

doi:卫生部科学研究基金

人参皂苷拮抗醋酸铅对大鼠胚胎发育毒性的研究

邹积艳¹，王学工²，黄冰玉³，李守柔³，胡晶³，刘立娟³

1. 吉林大学中日联谊医院妇产科，吉林长春130031；2. 解放军第208医院优生优育中心，吉林长春130051；3. 吉林大学第二医院妇产科，吉林长春130041

收稿日期:2003-01-15 修回日期:1900-01-01 出版日期:2004-03-28 发布日期:2004-03-28

Study on antagonism of ginsenoside to toxicity of embryodevelopment induced by acetic lead in rat

ZOU Ji-yan¹,WANG Xue-gong²,HUANG Bing-yu³,LI Shou-rou³,HU Jing³,LIU Li-juan³

1. Department of Obstetrics and Gynecology, China-Japan Union Hospital, Jilin University,Changchun 130031, China; 2. Improving Birth Outcome and Child Development Center, No.208 Hospital of PLA,Changchun 130051,China;3. Department of Obstetrics and Gynecology, Second Hospital, Jilin University,Changchun 130041,China

Received:2003-01-15 Revised:1900-01-01 Online:2004-03-28 Published:2004-03-28

摘要/Abstract

摘要： 目的：探讨人参皂苷对醋酸铅胚胎发育毒性的拮抗作用。方法：应用全胚胎体外培养技术建立胚胎致畸模型，并进行胚胎发育毒性的拮抗实验。结果：铅对大鼠胚胎有较强的发育毒性作用，并呈剂量—效应关系，人参皂苷可拮抗醋酸铅胚胎发育毒性，使胚胎正常生长。结论：人参皂苷对铅所致胚胎畸形有较好的拮抗作用，并可均衡地促进胚胎的分化和发育。

关键词: 胎儿发育, 毒性试验, 人参皂甙, 药理学

Abstract: Objective To explore the antagonism of ginsenoside to the toxicity of embryo development induced by acetic lead in rat. Methods The embryo teratogenic model in rat was established by whole embryo culture in vitro, antagonistic experiment was made with ginsenoside. Results Acetic lead had stronger developmental toxicity on rat embryo and the relationship of dose-effect was demonstrated, the developmental toxicity on rat embryo could be antagonized by ginsenoside. Ginsenoside could ensure normal growth of rat embryo. Conclusion Ginsenoside has better antagonism on embryo teratism in rat induced by acetic lead and can proportionately promote the differentiation and development of rat embryo.

Key words: fetal development, toxicity tests, panaxosides, pharmacology

中图分类号:

R-332

邹积艳，王学工，黄冰玉，李守柔，胡晶，刘立娟. 人参皂苷拮抗醋酸铅对大鼠胚胎发育毒性的研究[J]. J4, 2004, 30(2): 212-214.

ZOU Ji-yan,WANG Xue-gong,HUANG Bing-yu,LI Shou-rou,HU Jing,LIU Li-juan. Study on antagonism of ginsenoside to toxicity of embryodevelopment induced by acetic lead in rat[J]. J4, 2004, 30(2): 212-214.

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