关键词: 糖尿病, 实验性, 降血糖药

Abstract: To study the action of corn filament beverage (CFB)on falling blood sugar in diabetic rats and mice,provide scientific basis for application of corn filament extraction in falling sugar drug or functional food. Methods 60 rats were randomly divided into control group(pure water),alloxan model group,Kanglishu capsule (0.7 g•kg^-1) group,and 7.00,3.50,1.75 mL•kg^-1 CFB groups(n=10). the orbital vein blood samples were obtained,the contents of blood sugar were determined;The liver samples were obtained and the contents of liver glycogen were determined. 72 mice were randomly divided into control group(pure water),alloxan model group,Kanglishu capsule (1.0 g•kg^-1) group,and 10.0,5.0,0.25 mL•kg^-1 CFB groups(n=12),the indexes mentioned above were determined.72 mice were divided into 6 groups same as the method mentioned above,the mice were injected adrenalin hydrochloride through abdominal cavity,blood was extracted by decapitation,and the contents of blood sugar and liver glycogen were determined. Another 72 mice were divided and fed same as the method mentioned above,and the mice were injected glucose through caudal vein,the indexes mentioned above were detected. Results Compared with diabetic model rats,the contents of blood sugar in 7.00 and 3.50 mL•kg^-1 CFB groups were reduced obviously（P<0.01）,and the contents of liver glycogen increased obviously（P<0.01）,and 7.00 mL•kg^-1 CFB group was prior to 3.50 mL•kg^-1 CFB group.Compared with diabetic model mice,the contents of blood sugar in 10.0 and 5.0 mL•kg^-1 CFB groups were reduced obviously（P<0.01）,and the contents of liver glycogen increased obviously（ P<0.01,）,and 10.0 mL•kg^-1 CFB group was prior to 5.0 mL•kg^-1 CFB group. Compared with adrenine model mice,the contents of blood sugar in 10.0 mL•kg^-1 CFB group decreased obviously（P<0 .01）,and the contents of liver glycogen in 10.0 and 5.0 mL•kg^-1 CFB groups were increased obviously（P<0.05 or P<0.01）,the blood sugar of hyperglycemia mice in 10.0 mL•kg^-1 CFB group was obviously reduced because of exogenous glucose（P<0.05）,and the content of liver glycogen was obviously increased（P<0.01）. Conclusion CFB has the function of falling blood sugar on alloxan diabetic rats or mice and hyperglycaemia mice induced by adrenine and exogenous glucose.

Key words: diabetes mellitus, experimental , hypoglycemic agents