关键词: 四氯化碳, 保护作用

Abstract: Abstract:Objective To observe the protective effects of Jiangzhitong on carbon tetrachloride-induced chronic hepatic injury in rats and find its possible mechanisms. Methods Seventy two rats were randomly divided into 6 groups: control,model,positive control and jiangzhitong groups with different doses (50,100，200 mg•kg^-1•d^-1).　The effects of Jiangzhitong on hepatic injury were observed by measuring enzyme level (AST and ALT) in serum,reduced glutathione hormone(GSH) content and catalase(CAT) activity of hepatic tissue section. Results Compared with model group,the serum ALT and AST concentrations in Jiangzhitong groups with different doses were decreased significantly (P<0.05 or P<0.01),the GSH contents of hepatic tissue in Jiangzhitong groups with different doses were increased (P<0.05 or P<0.01).CAT activities were increased (P<0.05),Compared with positive control,the ALT concentration in high dose group was reduced obviously (P<0.01). There was no difference of ALT actvity between low,middle dose groups and control group(P>0.05).The ALT activity in high dose group was lower than those in low and middle dose groups,there was no difference of ALT activity between low and middle dose groups(P>0.05),the activities in middle and high doses groups were significantly lower than that in low dose group(P<0.05). Conclusion Jiangzhitong has the hepatoprotective effect on carbon tetrachloride-induced chronic hepatic injury in rats, its mechanism is likely related to potent antioxidative.

Key words: carbon tetrachloride, protective effect