关键词: 心肌, 骨骼肌细胞, 动物, 实验

Abstract: Objective To study the effects of growth hormone (GH) on morphology of cardiac muscle and skeletal muscle and hormone levels in Wistar rats. Methods The GH was given with subcutaneous injection for 15 days, the level of serum GH was determined by radiation-immune method; the body weight and the ratio of organ weight to body weight were determined; the cell appearances of cardiac muscle and skeletal muscle were observed under microscope. The control group was set up. Results The level of serum GH and rat body weight in experimental group were obviously higher than that in the control group, but the ratio of organ weight to body weight was not obviously different in two groups; musculature hypertrophy and cell nucleolus increasing were observed under microscope, there were no capillary vessel hyperplasia and inflammatory soakage. Conclusion GH can induce hypertrophy of cardiac muscle cells and skeletal muscle cells but not interstitial proliferation.

Key words: myocardium, musclu, skeletal, animal laboratory