硝酸银和滑石粉对兔胸膜的固定作用

硝酸银和滑石粉对兔胸膜的固定作用

刘伟，佟倜^*，王蕾，鄂长勇^Δ，李茁^Δ，刘国津

吉林大学第一医院胸外科，吉林长春130021

收稿日期:2003-06-08 修回日期:1900-01-01 出版日期:2005-03-28 发布日期:2005-03-28
通讯作者: 佟倜

Effects of pleurodesis with silver nitrate and talc in rabbits

LIU Wei, TONG Ti^*, WANG Lei,E Chang-yong^Δ, LI Zhuo^Δ, LIU Guo-jin

Department of Thoracic Surgery, First Hospital, Jilin University, Changchun 130021,China

Received:2003-06-08 Revised:1900-01-01 Online:2005-03-28 Published:2005-03-28
Contact: TONG Ti

摘要/Abstract

摘要： 目的：对比研究胸腔内注入硝酸银和滑石粉对兔胸膜的固定效果。方法：分别采用0.5％硝酸银溶液和滑石粉匀浆（400 mg•kg^-1）对日本大耳白兔进行实验性胸膜固定，检测术后1及3 d胸液量、胸液中白细胞计数（WBC）、多形核中性粒细胞百分比(PMN%)和乳酸脱氢酶(LDH)含量。比较术后1、3、7、14及28 d硝酸银和滑石粉匀浆组胸膜黏连情况。结果：硝酸银组术后1及3 d胸液量及WBC高于滑石粉组（P<0.001），且两组术后3 d兔胸液量及WBC均高于1 d(P<0.001)；两组术后1 d PMN%高于3 d(P<0.01)，硝酸银组术后3 d PMN%显著低于滑石粉组（P<0.001）。两组术后1 d LDH均高于3 d (P<0.001),而硝酸银组术后1和3 d胸液LDH含量高于滑石粉组（P<0.01）。术后胸膜黏连评分硝酸银组高于滑石粉组（P<0.05）。结论：0.5％硝酸银溶液和滑石粉匀浆均能诱导实验性兔胸膜固定作用，硝酸银胸膜固定效果好于滑石粉。

关键词: 滑石, 胸膜固定术

Abstract: Objective To study the effects of pleurodesis with the intrapleural injection of silver nitrate and talc in rabbits. Methods Intrapleural injection of 0.5% silver nitrate and talc slurry (400 mg•kg^-1), respectively, were performed to Japanese white rabbits to produce pleurodesis, the pleural effusion volume, white blood cell (WBC) numbers, the percentage of polymorphonuclear neutrophil (PMN%) and the content of lactate dehydrogenase (LDH) of 1 and 3 d after intrapleural injection were examined. The pleural adhesion scores of 1,3,7,14,28 d after pleurodesis in silver nitrate group and talc group were compared. Results The pleural effusion volume and WBC in silver nitrate group were higher than those in talc group at 1 and 3 d after pleurodesis (P<0.001), effusion volume and WBC at 3 d in the two groups were higher than those at 1 d (P<0.001); PMN% in both groups at 1 d were higher than those at 3 d (P<0.01), but it was lower at 3 d in silver nitrate group compared with talc group (P<0.001); the LDH contents in both groups at 1 d were higher than those at 3 d (P<0.001), and the LDH contents at 1 and 3 d in silver nitrate group were higher than those in talc group (P<0.01). The pleural adhesion score in silver nitrate group was higher than that in talc group (P<0.05). Conclusion Both silver nitrate and talc slurry can produce pleurodesis in rabbit pleura, and the low concentration of silver nitrate is superior to talc slurry.

Key words: talc, pleurodesis

中图分类号:

R655.2

刘伟，佟倜，王蕾，鄂长勇，李茁，刘国津. 硝酸银和滑石粉对兔胸膜的固定作用[J]. J4, 2005, 31(2): 281-283.

LIU Wei, TONG Ti, WANG Lei,E Chang-yong, LI Zhuo, LIU Guo-jin. Effects of pleurodesis with silver nitrate and talc in rabbits[J]. J4, 2005, 31(2): 281-283.