关键词: 放射摄影术, 支架P-选择素, 血液, 组织型纤溶酶原激活物, 血液, 纤溶酶原激活物抑制物, 血液

Abstract: Objective To evaluate the effects of Panax Notoginseng Saponins on P-selectin (Ps), tissue-type plasmiogen activitor (t-PA) and plasminoge activitor ihibitor-1 (PAI-1) levels in patients with acute coronary syndrome after intracoronary stent implantation. Methods Forty four patients with successful intracoronary stent implantation were divided into routine treatment group (control group,n=22)，routine combined with Lu-Lu-Tong (including Panax Notoginseng Saponins 25 g•L^-1) treatment group (treatment gorup,n=22) at random. For each case, 6 mL elbow venous blood were collected 24 h before implantation, 1 d and 1 month after implantation, and then the serum Ps, t-PA, and PAI-1 levels were detected by ABC-ELISA. Results The levels of Ps （9.170±1.500）g•L^-1 and PAI-1（0.584±0.075）kAU•L^-1 1 month after implantation were both significantly decreased (P<0.05), compared with 1 d after implantation. While the level of plasma t-PA （0.877±0.132）was significantly increased compared with control group. Conclusion Panax Notoginseng Saponins are beneficial to the patients after intracoronary stent implantation through regulating the t-PA/PAI system.

Key words: radiography, stents, P-selectin, blood, tissue plasminogen adivator, blood, plasminogen adivator inhibitor, blood