关键词: 念珠菌；定植；外阴阴道炎；糖尿病

Abstract:

Abstract:Objective To investigate the rate of vaginal colonization of Candida species in patients with diabetes,and to discuss the relationship between prevalence of vulvovaginal candidiasis（VVC） and diabetes mellitus (DM).Methods Genital tract examination and fungal cultures of discharge taken among 144 patients with DM (DM group) and 150 healthy subjects (control group) were performed.Chrom Agar Candida  mediums were used to study the isolates of 64 strains cultured in 144 participants.Results The isolated rates of Candida species were 44.4%（64/144）　in subjects with DM and 18%（27/150）in healthy subjects,the isolated rate of Candida species in DM group was prominently higher than that in control group (P<0.05).C.albicans were 75.0%（48/64）in DM group and  51.9%（14/27）in control group,the constituent ratio of C. albicans in DM group was higher than that in control group (P<0.05).The  isolated rates of Candida species were 64.3%（36/56） in symptomatic group and 31.8%（28/88） in asymptomatic group among patients with DM， the isolated rate of Candida species in symptomatic group was prominently higher than that in asymptomatic group (P<0.05).C. albicans were 88.8%（32/36）in symptomatic group and 57.1%（16/28）in asymptomatic group, the constituent ratio of C. albicans in symptomatic group was higher than that in asymptomatic group (P<0.05). Candida glabrata were 2.8%（1/36）in symptomatic group and 28.6%（8/28）in asymptomatic group, the constituent ratio of Candida glabrata in asymptomatic group was higher than that in symptomatic group (P<0.05).Conclusion Patients with DM have a high risk of vaginal colonization.It seems that Candida albicans is a major pathogenic strain and Candida glabrata is significant in asymptomatic patients with DM.

Key words: Candida；colonization；vulvovaginal candidiasis；diabetes mellitus