亚麻籽木脂素对大鼠前列腺增生的抑制作用及其机制

J4 ›› 2011, Vol. 37 ›› Issue (2): 288-291.

亚麻籽木脂素对大鼠前列腺增生的抑制作用及其机制

沈楠¹|任旷²|王艳春²|范红艳²|顾饶胜²

1.吉林医药学院医学实验中心,吉林吉林 132013；2.吉林医药学院基础医学院药理学教研室|吉林吉林 132013

收稿日期:2010-11-17 出版日期:2011-03-28 发布日期:2011-03-28
通讯作者: 顾饶胜（Tel：0432-64560469，E-mail：gurs@163.com） E-mail:gurs@163.com
作者简介:沈楠（1972-）|女|吉林省吉林市人|副教授|医学硕士|主要从事生殖药理学实验方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（200705405）

Inhibitory effect of secoisolariciresinol diglusoside on hyperplasia of prostate in rats and its mechanism

SHEN Nan¹,REN Kuang²,WANG Yan-chun ²,FAN Hong-yan²,GU Rao-sheng ²

1. Experimental Center,Jilin Medical College,Jilin 132013,China;2. Departmentof Pharmacology,School of Basic Medical Sciences,Jilin Medical College,Jilin 132013,China

Received:2010-11-17 Online:2011-03-28 Published:2011-03-28

摘要/Abstract

摘要：

目的：研究亚麻籽木脂素(SDG)对丙酸睾酮诱导的大鼠前列腺增生的抑制作用，并阐明其作用机制。方法：50只雄性Wistar大鼠随机分为空白组、模型组、阳性药(非那雄胺1.0 mg·kg-1)组及SDG（1.2和0.4 g·kg^-1）组。ELISA方法检测前列腺组织中一氧化氮（NO）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、肿瘤坏死因子α（TNF-α）、碱性成纤维细胞生长因子（bFGF）和白细胞介素8（IL-8）的变化。结果：模型组大鼠前
列腺组织中NO、SOD和CAT水平均低于空白组（P<0.01），TNF-α、bFGF和IL-8水平均高于空白组（P<0.01）；SDG 1.2 g·kg^-1组NO、SOD和CAT水平均高于模型组（P<0.01），TNF-α、bFGF和IL-8水平均低于模型组（P<0.01）。结论：SDG抑制睾酮诱导的大鼠前列腺增生的机制可能与提高抗氧化酶活力、清除自由基及减少TNF-α、bFGF和IL-8相关因子含量有关。

关键词: 亚麻籽木脂素；前列腺增生；自由基；细胞因子

Abstract:

Abstract:Objective To study the inhibitory effect of secoisolariciresinol diglusoside (SDG) on hyperplasia of prostate induced by testosterone in rats and clarify itsmechanism. Methods Fifty male Wistar rats were randomly divided into control group,model groups,finasteride (1.0 mg·kg^-1) group and SDG (1.2 and 0.4g·kg^-1) groups. The levels of NO,SOD,CAT, TNF-α,bFGF and IL-8 in prostate tissues were detected by ELISA method. Results Compared with control group,the levels of NO,SOD and CAT in prostate tissues of rats in model group were decreased(P<0.01),and the levels of TNF-α,bFGF and IL-8 in model group were increased(P<0.01).Compared with model group,the levels of SOD,CAT and NO in SDG 1.2 g·kg^-1 group were increased(P<0.01),and the levels of TNF-α,bFGF and IL-8 in SDG 1.2 g·kg^-1 group were decreased(P<0.01). Conclusion The mechanism of inhibitory effects of SDG on hyperplasia of prostate induced by testosterone may be concerned with enhancing the activity of antioxidase,clearing away free radical and decreasing the levels of TNF-α,bFGF and IL-8 in rats．

Key words: secoisolariciresinol diglusoside；hyperplasia of prostate；free radical；cytokine

中图分类号:

R285.5

沈楠|任旷|王艳春|范红艳|顾饶胜. 亚麻籽木脂素对大鼠前列腺增生的抑制作用及其机制[J]. J4, 2011, 37(2): 288-291.