抗精神分裂症药物诱发迟发性运动障碍与COMT基因多态性的关联性分析

J4 ›› 2011, Vol. 37 ›› Issue (3): 487-490.

抗精神分裂症药物诱发迟发性运动障碍与COMT基因多态性的关联性分析

刘姗姗¹|张逸远^*|于跃^*|孙颖¹|赵刚²|孙世龙²|王宝贵¹|刘颖³

1.吉林大学公共卫生学院营养与食品卫生学教研室,吉林长春 130021；2.吉林大学公共卫生学院卫生部放射生物学重点实验室|吉林长春 130021；3.吉林大学公共卫生学院卫生毒理学教研室,吉林长春 130021

收稿日期:2010-10-17 出版日期:2011-05-28 发布日期:2011-05-28
通讯作者: 刘颖（Tel：0431-85619433，E-mail：liuying7801@yahoo.com.cn） E-mail:sunsl77@yahoo.com.cn
作者简介:刘姗姗（1986-）|女|吉林省蛟河市人|在读医学硕士,主要从事基因组学研究。
基金资助:
吉林大学基本科研业务费项目资助课题（200903117）;国家自然科学基金青年基金
项目资助课题（30700672）；吉林省科技厅科研基金资助课题（20090932）

Analysis on association between COMT gene polymorphism and tardive |dyskinesia induced by antipsychotic drugs

LIU Shan-shan¹,ZHANG Yi-yuan*,YU Yue*,SUN Ying¹,ZHAO Gang²,SUN Shi-long²,WANG Bao-gui¹,LIU Ying³

1. Department of Nutrition and Food Hygiene, School of Public Health,Jilin University,Changchun 130021,China ;2. Key Laboratory of Radiobiology,Ministry of Health,School of Public Health,Jilin University,Changchun 130021,China;3. Department of Hygiene Toxicology,School of Public Health,Jilin University,Changchun 130021,China

Received:2010-10-17 Online:2011-05-28 Published:2011-05-28

摘要/Abstract

摘要：

目的：通过分析中国北方汉族人群中精神分裂症患者COMT基因多态性Val158Met 分布，研究COMT基因多态性与精神分裂症及迟发性运动障碍(TD)发生的关系。方法：采集356例并发TD的精神分裂症患者( TD组)、419例不发生TD的精神分裂症患者(非TD组)及471例正常健康人(正常对照组)的全血样本，提取基因组DNA，应用TaqMan探针检测COMT基因多态性Val158Met基因型和等位基因的分布。结果：正常对照组与精神分裂症组比较，基因型与等位基因频数分布差异均无统计学意义（χ²=3.08，df=3，P=0.21；χ²=2.067，df=2，P=0.15）。TD组与正常对照组
比较，基因型与等位基因频数分布差异均无统计学意义(χ²=1.857，df=3，P=0.40；χ²=1.281，df=2，P=0.26)。非TD组与正常对照组比较，基因型与等位基因频数分布差异均无统计学意义(χ²=2.505，df=3，P=0.29；χ²=1.709，df=2，P=0.19)。TD组与非TD组比较，基因型与等位基因频数分布差异均无统计学意义(χ²=0.021，df=3，P=0.99；χ²=0.013，df=2，P=0.91)。结论：精神分裂症的发生与COMT基因多态性Val158Met无关联性，精神分裂症患者并发TD与COMT基因多态性Val158Met无关联性。

关键词: 儿茶酚胺氧位甲基转移酶基因;基因多态性；精神分裂症;迟发性运动障碍

Abstract:

Abstract:Objective To observe the distribution of COMT gene polymorphism Val158Met in Chinese patients with schizophrenia and investigate the possible association between COMT gene polymorphism and schizophrenia and tardive dyskinesia (TD).
Methods The whole blood samples from 356 schizophrenic patients with TD (TD group),419 schizophrenic patients without TD (non-TD group)and 471 cases of normal healthy subjects(control group) were collected,the DNA was extracted,the distribution of genotype and allele of COMT gene polymorphism Val158Met was detected by Taqman assays. Results Compared between schizophrenic patients group and normal control group,the allelic frequency and genotypic frequency of rs4680 hadn’t significant differences（χ²=3.08,df=3,P=0.21;χ²=2.067,df=2,P=0.15）. Compared between TD group and normal control group,the allelic frequency and genotypic frequency of rs4680 hadn’t significant differences (χ²=1.857,df=3,P=
0.40;χ2 =1.281,df=2,P=0.26). Compared between non-TD group and normal control group,the allelic frequency and genotypic frequency of rs4680 hadn’t significant differences (χ²=2.505,df=3,P=0.29;χ²=1.709,df=2,P=0.19). Compared with TD group and non-TD group,the frequencies of allele and genotype of rs4680 hadn’t significant differences (χ²=0.021,df=3,P=0.99;χ²=0.013,df=2,P=0.91).Conclusion The Val158Met polymorphism of COMT gene isn’t associated with schizophrenia and TD.

Key words: catechol-O-methyltransferase gene;gene polymorphism;schizophrenia;tardive dyskinesia

中图分类号:

R749.3

刘姗姗, 张逸远, 于跃, 孙颖, 赵刚, 孙世龙, 王宝贵, 刘颖. 抗精神分裂症药物诱发迟发性运动障碍与COMT基因多态性的关联性分析[J]. J4, 2011, 37(3): 487-490.

LIU Shan-Shan, ZHANG Yi-Yuan, YU Yue, SUN Ying, ZHAO Gang, SUN Shi-Long, WANG Bao-Gui, LIU Ying. Analysis on association between COMT gene polymorphism and tardive |dyskinesia induced by antipsychotic drugs[J]. J4, 2011, 37(3): 487-490.