盐酸阿比朵尔多层缓释片的制备及体内外释放度的评价

J4 ›› 2009, Vol. 35 ›› Issue (4): 758-761.

盐酸阿比朵尔多层缓释片的制备及体内外释放度的评价

张淑芹¹|刘志屹¹|张福明²|孙非¹

1.吉林大学再生医学科学研究所细胞生物学研究室|吉林长春 130021；2.吉林大学第一医院血液肿瘤科|吉林长春 130021

收稿日期:2008-10-16 出版日期:2009-07-28 发布日期:2009-08-24
作者简介:张淑芹（1965-）|女|吉林省长春市人|高级工程师|主要从事病毒性心肌炎及药物研究。
基金资助:
吉林省科技厅科研基金资助课题（20070412）

Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro

ZHANG Chu-Qin¹, LIU Zhi-Yi¹, ZHANG Fu-Ming², SUN Fei¹

1.Department of Cytobiology,Institute of Frontier Medical Science,Jilin University,Changchun 130021,China|2. Department of Hematology and Oncology,First Hospitai,Jilin University|Changchun 130021,China

Received:2008-10-16 Online:2009-07-28 Published:2009-08-24

摘要/Abstract

摘要：

目的：探讨盐酸阿比朵尔多层缓释片的研制及体内外释药评价，为盐酸阿比朵尔多层缓释片的药效学研究提供实验依据。方法：以自制的盐酸阿比朵尔多层缓释片为实验组，以盐酸阿比朵尔单方片剂为对照组，采用高效液相色谱法（ＨＰＬＣ）测定两组实验的体内外释放度，并计算药动学参数及相对生物利用度。结果：盐酸阿比朵尔多层缓释片与盐酸阿比朵尔单方片剂比较，峰浓度C_max显著降低(P<0.01)，达峰时间T_max明显后移(P<0.01)，吸收半衰期T_1／2ka和消除半衰期T_1／2ke明显延长(P<0.01)，峰面积AUC(0-10)显著增加(P<0.01)，药物体内平均滞留时间MRT明显延长(P<0.01)；其药效可维持12 ｈ以上,相对生物利用度为189.3% 。结论:盐酸阿比朵尔多层缓释片制备工艺简单，稳定性好，药效持久，符合设计要求。

关键词: 盐酸阿比朵尔；多层缓释片；释放度

Abstract:

Abstract:Objective To study the development of Arbidol hydrochloride(Ahyd) multi-layers controlled-released preparation and evaluate its release rate in order to provide the basis for Ahyd pharmacodynamics reseach. Methods Ahyd multi-layers was used as experiment group and Ahyd single-layer as control,high performance liquid chromatography (HPLC) was used to examine releasing level of two groups for calculating parameters of drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as below:C_maxfell remarkably(P<0.01);T_max,T_1/2ka,T_1/2ke,AUC_(0-10) and (MRT) increased(P<0.01).The multi-layers preparation could maintain 12 h,its relative bioavailability reached 189.3%. Conclusion The multi-layers controlled-released preparation of Ahyd has simple technique,better stability and permanent effect,all of which have met designed requirements.

Key words: arbidol hydrochloride; , multi-layers controlled-released preparation;release rate

中图分类号:

R969.1

张淑芹, 刘志屹, 张福明, 孙非. 盐酸阿比朵尔多层缓释片的制备及体内外释放度的评价[J]. J4, 2009, 35(4): 758-761.

ZHANG Chu-Qin, LIU Zhi-Yi, ZHANG Fu-Ming, SUN Fei. Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro[J]. J4, 2009, 35(4): 758-761.