信号转导及转录活化因子3蛋白在乳腺癌组织中的表达及其临床意义

J4 ›› 2011, Vol. 37 ›› Issue (1): 72-75.

信号转导及转录活化因子3蛋白在乳腺癌组织中的表达及其临床意义

李嗣杰, 贾泓瑶, 韩冰, 吴迪, 付彤

吉林大学第一医院乳腺外科|吉林长春130021

收稿日期:2010-10-09 出版日期:2011-01-28 发布日期:2011-01-28
作者简介:李嗣杰(1977-)|男|吉林省长春市人|主治医师|医学博士|主要从事乳腺疾病的诊断和治疗研究。

Expression of STAT3 protein in human breast cancer tissue and its clinical significances

LI Si-Jie, JIA Hong-Yao, HAN Bing, WU Di, FU Tong

Department of Breast Surgery,First Hospital,Jilin University,Changchun 130021,China

Received:2010-10-09 Online:2011-01-28 Published:2011-01-28
Contact: 付彤（ Tel:0431-88782284,E-mail:xxli@jlu.edu.cn） E-mail:xxli@jlu.edu.cn
Supported by:
中国-加拿大大学合作项目资助课题（Sulcp010#）；吉林大学基本科研业务费资助课题（421030170428）

摘要/Abstract

摘要：

目的: 检测人信号转导及转录活化因子3（STAT3）蛋白在乳腺癌组织中的表达，探讨其与乳腺癌患者临床病理参数及预后的关系。方法: 应用免疫组织化学SP法检测67例乳腺癌及其配对正常乳腺组织中STAT3蛋白的表达水平，分析具有不同临床病理参数患者间STAT3的表达情况。结果: STAT3蛋白在乳腺癌组织的表达水平明显高于正常乳腺组织（P<0.001），STAT3表达水平与乳腺癌患者年龄、肿瘤大小和组织学类型无关联性（P>0.05），与乳腺癌临床分期、淋巴结转移情况及患者生存时间有关联（P<0.05）。临床分期越高的乳腺癌组织中STAT3的表达阳性率越高（P<0.05）；有淋巴结转移者STAT3阳性表达率明显高于无淋巴结转移者（P<0.05）；STAT3阳性表达的患者生存时间［（51.1±4.4)月］明显短于阴性表达的患者［（86.0±4.9)月］（P<0.05）。结论: STAT3蛋白的过表达可能在乳腺癌的发生发展过程中发挥了促进作用，并且是乳腺癌患者预后不良的一个重要指标。

关键词: 乳腺肿瘤；信号转导及转录活化因子3；预后；蛋白表达；免疫组织化学

Abstract:

Abstract:Objective
To investigate the expression level of STAT3 protein in human breast cancer tissues and corresponding adjacent normal mammary tissues,and clarify the relationship between STAT3 expression and clinical characters in patients with breast cancer. Methods The expressions of STAT3 protein in 67 human breast cancer tissues and the corresponding adjacent normal mammary tissues were detected by immunohistochemical technique.The expressions of STAT3 protein in patients with different clinicopathological parameters were analyzed. Results The expression rate of STAT3 protein in 67 human breast cancer tissues was 62.69% (42/67) which was significantly higher than that in normal mammary tissues (25.37%,P<0.001). The expression level of STAT3 had no correlation with the age,tumor size and histological type in patients with breast cancer(P>0.05),but the expression of STAT3 protein was positively correlated with clinical stage,lymph node metastasis and survival time in patients with breast cancer. The mean survival time of the patients with high expression of STAT3 protein was shorter than that of the patients with low expression of STAT3 protein(P<0.05). Conclusion STAT3 protein over-expression may play a promotion role in the tumorigenesis and development of breast cancer,and may be an important prognostic factor in breast cancer.

Key words: breast neoplasms;signal transducers and activators of transcription;prognosis;protein expression;immunohistochemistry

中图分类号:

Q786

李嗣杰, 贾泓瑶, 韩冰, 吴迪, 付彤. 信号转导及转录活化因子3蛋白在乳腺癌组织中的表达及其临床意义[J]. J4, 2011, 37(1): 72-75.

LI Si-Jie, JIA Hong-Yao, HAN Bing, WU Di, FU Tong. Expression of STAT3 protein in human breast cancer tissue and its clinical significances[J]. J4, 2011, 37(1): 72-75.