朝鲜族和汉族人群原发性高血压与ACE基因多态性的关系

J4 ›› 2009, Vol. 35 ›› Issue (5): 906-909.

朝鲜族和汉族人群原发性高血压与ACE基因多态性的关系

戚小华¹,蔡知天²|王春华³,杨平¹|金银花¹|张治富¹,全成实⁴|韩春姬⁵|李忠民¹

1. 吉林大学公共卫生学院流行病和卫生统计学教研室|吉林长春 130021；2. 吉林大学第一医院妇产科|吉林长春 130021；3. 吉林大学公共卫生学院环境卫生学教研室|吉林长春 130021；4. 吉林大学基础医学院病理生物学教育部重点实验室|吉林长春 130021；5. 延边大学卫生毒理学教研室,吉林延吉 133002

收稿日期:2009-04-23 出版日期:2009-09-28 发布日期:2009-09-28
通讯作者: 李忠民 E-mail:lzhmin@yahoo.com
作者简介:戚小华(1979-)|男|陕西省西安市人|医学硕士,主要从事慢性病流行病学研究。
基金资助:
国家自然科学基金资助课题（30560134）

Association between polymorphism of ACE gene and primaryhypertension in Korean and Han nationalities

QI Xiao-Hua¹, CAI Zhi-Tian², WANG Chun-Hua³, YANG Ping¹, JIN Yin-Hua¹, ZHANG Zhi-Fu¹, QUAN Cheng-Shi⁴, HAN Chun-Ji⁵, LI Zhong-Min¹

1.Department of Epidemiology and Health Statistics,School of Public Health,Jilin University,Changchun 130021,China;2 . Department of Obstetrics and Gynecology,First Hospital,Jilin University,Changchun 130021,China;3 .Department of Environment Hygiene,School of Public Health,Jilin University,Changchun 130021,China;4. Key Laboratory of Pathobiology,Ministry of Education,School of Basic Medical Sciences,Jilin University,Changchun 130021,China;5. Department of Health Toxicology,Yanbian University,Yanji 133002,China

Received:2009-04-23 Online:2009-09-28 Published:2009-09-28

摘要/Abstract

摘要：

目的：探讨血管紧张素Ⅰ转换酶（ACE）基因多态性与朝鲜族和汉族居民原发性高血压（EH）的关系。方法：采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测106例高血压患者（病例组）和105名健康人（对照组）的 ACE基因型。应用拟合优度χ2检验分析基因型频数分布是否符合Hardy-Weinberg平衡定律；利用SPSS 13.0统计软件分析等位基因和基因型与原发性高血压的关系。结果: 病例组与对照组ACE基因各基因型频数均符合Hardy-Weinberg平衡定律（P>0.05）；病例组和对照组ACE基因3种基因型（II、DD和ID）和等位基因（I、D）频数分布比较差异均无显著性(P>0.05)。朝鲜族人群高血压组和非高血压组ACE基因型和等位基因频数分布差异无显著性（P>0.05），汉族人群高血压组和非高血压组ACE基因型和等位基因频数分布差异无显著性（P>0.05）；朝鲜族高血压组和汉族高血压组比较ACE基因型和等位基因频数分布差异无显著性（P>0.05）,朝鲜族非高血压组和汉族非高血压组比较ACE基因型和等位基因频数分布差异无显著性（P>0.05）。结论：ACE基因多态性可能与朝鲜族和汉族原发性高血压发病无关。

关键词: 原发性高血压；血管紧张素转换酶；朝鲜族；多态性,单核苷酸

Abstract:

Abstract:Objective To explore the association between polymorphism of ACE gene and primary hypertension in Korean and Han nationalities.Methods The ACE gene polymorphism in 106 patients with hypertension(case group) and 105 healthy controls(control group) were examined by polymerase chain reaction-restriction frag
ment length polymorphism (PCR-RFLP).Hardy-Weinberg equilibrium for genotypic distribution was tested using Chi-square test of goodness of fit.SPSS13.0 was applied to analyze the association between allelic gene and genotypic distribution and primary hypertension. Results The genotypic frequency distribution of ACE gene was not deviated from Hardy-Weinberg equilibrium in both case group and control group(P>0.05).The genotypic（I,DD and ID）and allelic frequencies(I,D) of ACE gene had no significant difference between case and control groups(P>0.05).There were no remarkable differences of genotypic frequency and allelic frequency of ACE gene between case and control groups of Korean nationalities (P>0.05).There were no remarkable differences of genotypic frequency and allelic frequency of ACE gene between case and control groups of Han nationalities(P>0.05).And the genotypic frequency and allelic frequency of ACE gene had no statistically significant difference among Korean and Han nationalities in healthy samples (P>0.05),the genotypic frequency and allelic frequency of ACE gene had no statistically significant difference among Korean and Han nationalities in healthy controls(P>0.05).Conclusion The polymorphism of ACE gene may not be associated with primary hypertension in Korean and Han nationalities.

Key words: primary hypertension;angiotensin converting enzyme;korean;polymorphisms,single nucleotide

中图分类号:

戚小华, 蔡知天, 王春华, 杨平, 金银花, 张治富, 全成实, 韩春姬, 李忠民. 朝鲜族和汉族人群原发性高血压与ACE基因多态性的关系[J]. J4, 2009, 35(5): 906-909.

QI Xiao-Hua, CAI Zhi-Tian, WANG Chun-Hua, YANG Ping, JIN Yin-Hua, ZHANG Zhi-Fu, QUAN Cheng-Shi, HAN Chun-Ji, LI Zhong-Min. Association between polymorphism of ACE gene and primaryhypertension in Korean and Han nationalities[J]. J4, 2009, 35(5): 906-909.

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