奎硫平与氟哌啶醇治疗精神分裂症疗效及安全性的Meta分析

J4 ›› 2010, Vol. 36 ›› Issue (1): 169-174.

奎硫平与氟哌啶醇治疗精神分裂症疗效及安全性的Meta分析

方芳¹, 王志成², 姚燕³, 李波³, 刘娅¹

1.吉林大学公共卫生学院营养与食品卫生学教研室|吉林长春 130021；2.吉林大学公共卫生学院卫生部放射生物学重点实验室|吉林长春 130021；3.吉林大学公共卫生学院流行病学与卫生统计学教研室|吉林长春 130021

收稿日期:2009-09-23 出版日期:2010-01-28 发布日期:2010-01-28
通讯作者: 李波(Tel：0431-85619437，E-mail：li_bo@jlu.edu.cn)；刘娅(Tel：0431-85166356，E-mail：liuya@jlu.edu.cn) E-mail:li_bo@jlu.edu.cn；liuya@jlu.edu.cn
作者简介:方芳(1981-)|女|吉林省白城市人|在读医学博士|主要从事精神药理学与食品毒理学研究。
基金资助:
国家科技部“863”计划合作项目资助课题(2007AA03Z320)

Meta-analysis on efficacy and safety of quetiapine and haloperidol in treatment of schizophrenia

FANG Fang¹, WANG Zhi-Cheng², YAO Yan³, LI BO³, LIU Ya¹

1. Department of Nutrition and Food Hygiene,School of Public Health,Jilin University,Changchun 130021,China;2. Key Laboratory of Radiobiology,Ministry of Health,School of Public Health,Changchun 130021,China;3. Department of Epidemiology and Health Statistics,Shoo1 of Public Health,Jilin University,Changchun 130021,China

Received:2009-09-23 Online:2010-01-28 Published:2010-01-28

摘要/Abstract

摘要：

目的：了解奎硫平与氟哌啶醇治疗精神分裂症的疗效及不良反应差异。方法：应用Meta分析对14篇研究奎硫平与氟哌啶醇治疗精神分裂症疗效及安全性的文献进行再分析，评价其合并总有效率、痊愈率、显效率及不良反应发生率。结果：①奎硫平与氟哌啶醇治疗精神分裂症总有效率合并分析总有效率之间差异无显著性（P=0.76）；②奎硫平与氟哌啶醇治疗精神分裂症的痊愈率合并分析二者差异具有显著性（P=0.04）；③与氟哌啶醇比较，奎硫平治疗精神分裂症的显效率更高（P=0.006）；④奎硫平组的震颤、静坐不能、肌强直、口干和视物模糊等不良反应的发生率低于氟哌啶醇组（P<0.05），其余不良反应发生率二者之间比较差异均无显著性。结论：奎硫平与氟哌啶醇治疗精神分裂症总有效率相当，但奎硫平治疗精神分裂症的痊愈率及显效率明显好于氟哌啶醇；与氟哌啶醇比较，奎硫平可显著降低锥体外系反应的发生率。

关键词: 奎硫平；氟哌啶醇；精神分裂症；Meta分析

Abstract:

Abstract:Objective To assess the efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia and the differences in adverse effects of them．Methods Meta analysis on the 14 papers about efficacy and safety of quetiapine and haloperidol in the treatment of schizophrenia was performed,and the total effective rate,cure ratative,obvious effective rate and adverse effects were evaluated.Results ①Haloperidol and quetiapine had similar total effective rate (P=0.76);②there was significant difference of curative rate between haloperidol and quetiapine in treatment of schizophrenia(P=0.04);③Compared with haloperidol,quetiapine had a higher obvious effective rate(P=0.006);④the incidence rates of akathisia,myotonia,dry mouth etc in quetiapine group were lower than those in haloperidol group (P<0.05).Conclusion Quetiapine is better than haloperidol on the cure rate and obvious effective rate in the treatment of schizophrenia．Further,quetiapine has less extrapyramidal reactions.

Key words: quetiapine；haloperidol；schizophrenia;meta , analysis

中图分类号:

R749.3

方芳, 王志成, 姚燕, 李波, 刘娅. 奎硫平与氟哌啶醇治疗精神分裂症疗效及安全性的Meta分析[J]. J4, 2010, 36(1): 169-174.

FANG Fang, WANG Zhi-Cheng, YAO Yan, LI BO, LIU Ya. Meta-analysis on efficacy and safety of quetiapine and haloperidol in treatment of schizophrenia[J]. J4, 2010, 36(1): 169-174.

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