关键词: 痰热清注射液；辐射；黏膜损伤；头颈部恶性肿瘤, 口腔咽喉炎

Abstract:

Objective To observe the therapeutic effect of Tanreqing Injection in treatment of acute irradiation oropharyngeal mucositis in the patients with head and neck cancer, and to provide reference for its clinical application．Methods Fifty patients with head and neck cancer were randomly divided into treatment group and control group(n=25)．The patients in treatment group received concurrently intravenous infusion of Tanreqing Injection during irradiation course. The patients in control group received daily regular oral nursing；oropharyngeal mucositis was evaluated according to the protocol proposed by RTOG. Results  The patients in  treatment group with Ⅰ and  Ⅱ oropharyngeal mucosal injury accounted for 76%,and the patients in  control group with Ⅲ, Ⅳ oropharyngeal mucosal  injury accounted  for 60%, there was  statistically significant difference between two groups (P<0.05).The scores of the  patients with oropharyngeal pain in treatment group  were 0-3 (mild), in control group they were  4- 6 (moderate).The  patients with mild,moderate,and severe oropharyngeal pain in treatment group and control group  after radiotherapy accounted for 72％,24％,4％ and 12％,64％,24％;there were statistically significant differences between two groups (P<0.05).Conclusion Tanreqing Injection has a good therapeutic effect on acute radiation stomatitis and  layngopharyngitis，and it has the effects of relieving oral and pharyngeal mucosa injury, anti-inflammatory and analgesic and accelerating wound healing.

Key words: Tanreqing , Injection；radiation；mucosal injury, head and neck neoplasms;stomatitis and layngophargngitis