关键词:  , 前列腺肿瘤, 慢性前列腺炎；超声血流动力学；微血管密度

Abstract:

Objective To study the application value of microvascular density(MVD) in determination of transrectal ultrasound hemodgynamics in the differential diagnosis of prostate cancer and chronic prostatitis,and to provide imageological basis for their differential diagnosis.Methods A total of 61 patients suspected of  prostate cancer underwent transrectal ultrasound scan and ultra
sound guided biopsy.38 cases of prostate cancer and 23 cases of chronic prostatitis were confirmed by pathology and retrospectively analyzed.The peak systolic blood flow velocity (Vs)  and blood flow classification of the  suspicious lesions were compared and analyzed.The MVD was observed by Weidner method with monoclonal antibody CD34 immunohisochemistry staning.Results The Vs and the blood flow classification of the suspicious lesions in  prostate cancer group were significant higher than those in chronic prostatitis group  (P<0.05).The MVD in prostate cancer group and chronic prostatitis group were 46.70±13.87 and 34.38±7.28,respectively(P<0.05);the MVD in prostate cancer (C+D)stage and (A+B)stage were 56.99±12.85 and 39.97±10.21,respectively(P<0.05);the MVD in prostate cancer with high Gleason score group and low Gleason score group were 53.79±13.30 and 36.96±7.24,respectively(P<0.05).The Vs and the blood flow classification of the suspicious lesions of prostate cancer had a significantly positive correlation with the MVD　(r=0.793,P<0.05;r=0.723,P<0.05).Conclusion The Vs and the blood flowclassification of prostate cancer by ultrasound can well reflect the changes of the micrangium in tumor tissue.The  Vs and blood supply grade of suspicious lesions in the patients with prostate cancer are significantly higher than those in the patients with chronic prostatitis.They may be useful for the identification of prostate cancer and chronic prostatitis.

Key words: prostate neoplasms, chronic prostatitis, ultrasonic hemodgynamics, microvascular density