自体骨髓干细胞移植联合经皮腔内血管成形术治疗糖尿病足的效果评价

doi:10.13481/j.1671-587x.20160125

吉林大学学报(医学版) ›› 2016, Vol. 42 ›› Issue (01): 125-129.doi: 10.13481/j.1671-587x.20160125

自体骨髓干细胞移植联合经皮腔内血管成形术治疗糖尿病足的效果评价

韩雪立¹, 刘东¹, 张秀娟², 周盈¹

1. 吉林大学第二医院放射线科, 吉林长春 130041;
2. 吉林大学第二医院内分泌科, 吉林长春 130041

收稿日期:2015-05-08 发布日期:2016-01-26
通讯作者: 张秀娟,主任医师,硕士研究生导师(Tel:0431-88796784,E-mail:zmxiujuan@163.com) E-mail:zmxiujuan@163.com
作者简介:韩雪立(1962-),男,吉林省长春市人,教授,主任医师,主要从事影像医学诊断及介入方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题(20130413006GH)

Evaluation effect of autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty in treatment of diabetic foot

HAN Xueli¹, LIU Dong¹, ZHANG Xiujuan², ZHOU Ying¹

1. Department of Radiology, Second Hospital, Jilin University, Changchun 130041, China;
2. Department of Endocrinology, Second Hospital, Jilin University, Changchun 130041, China

Received:2015-05-08 Published:2016-01-26

摘要/Abstract

摘要：

目的: 探讨自体骨髓干细胞移植与经皮腔内血管成形术相结合方法治疗糖尿病足的优点,阐明该方法独特的临床疗效。方法: 将糖尿病足且下肢血管重度狭窄或闭塞40例患者,按患者意愿分为2组,其中采用自体骨髓干细胞移植联合经皮腔内血管成形术治疗的20例患者为联合治疗组,行自体骨髓干细胞移植治疗的20例患者为单独移植组。2组患者均进行常规治疗,观察2组患者治疗前后患侧肢体疼痛、冷感、间歇性跛行、踝肱指数(ABI)和侧支血管生成数量的变化,比较2组患者疗效。结果: 与治疗前比较,联合治疗组和单独移植组患者治疗后肢体疼痛评分、冷感评分和间歇性跛行评分均明显降低(P<0.01),ABI和侧支血管生成数量评分均明显升高(P<0.01)。与单独移植组比较,联合治疗组患者肢体总疼痛评分、总冷感评分和总间歇性跛行评分明显减低(P<0.05),ABI和侧支血管生成数量评分明显升高(P<0.05)。以患者溃疡面的变化情况为疗效判定标准,联合治疗组患者临床治愈率较单独移植组高,有效率较单独移植组低。结论: 自体骨髓干细胞移植与经皮腔内血管成形术结合是治疗糖尿病足的安全而有效方法。

关键词: 糖尿病足, 干细胞移植, 血管腔内成形术

Abstract:

Objective: To investigate the advantages of autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty in treatment of diabetic foot,and to clarify the clinical effect of this method.Methods: 40 patients with diabetic foot and lower limb blood vessel severe stenosis or occlusion were divided into 2 groups.20 patients treated with autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty were used as combined treatment group,and the other 20 patients treated with autologous bone marrow stem cell transplantation alone were used as single transplation group. The patients in two groups receieved conventional therapy. The limb pain,cold feeling,intermittent claudication,ankle brachial index(ABI)and the number of collateral vessel formation of the patients in two groups were observed before and after treatment,and the curative effects in two groups were compared. Results: Compared with before treatment,the limb pain scores,cold feeling scores and intermittent claudication scores of the patients in two groups after treatment were significantly decreased(P<0.01),and the ABI and the number of collateral vessel formation were significantly increased (P<0.01). The clinical cure rate of the patients in combined treatment group was higher than that in single transplantation group,but the effective rate in combinaed treatment group was lower than that in single transplantation group. Conclusion: Autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty is a safe and effective method for the treatment of diabetic foot.

Key words: diabetic foot, stem cell transplantation, percutaneous transluminal angioplasty

中图分类号:

R587.1

韩雪立, 刘东, 张秀娟, 周盈. 自体骨髓干细胞移植联合经皮腔内血管成形术治疗糖尿病足的效果评价[J]. 吉林大学学报(医学版), 2016, 42(01): 125-129.

HAN Xueli, LIU Dong, ZHANG Xiujuan, ZHOU Ying. Evaluation effect of autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty in treatment of diabetic foot[J]. Journal of Jilin University Medicine Edition, 2016, 42(01): 125-129.

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自体骨髓干细胞移植联合经皮腔内血管成形术治疗糖尿病足的效果评价

Evaluation effect of autologous bone marrow stem cell transplantation combined with percutaneous endovascular angioplasty in treatment of diabetic foot

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