重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义

doi:10.13481/j.1671-587x.20170626

吉林大学学报(医学版) ›› 2017, Vol. 43 ›› Issue (06): 1209-1214.doi: 10.13481/j.1671-587x.20170626

重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义

尚涛, 任艳丽, 李静, 张英

吉林省人民医院内分泌二科, 吉林长春 130021

收稿日期:2017-03-29 出版日期:2017-11-28 发布日期:2017-12-01
通讯作者: 张英,主任医师,硕士研究生导师(Tel:0431-85595215,E-mail:1273360266@qq.com) E-mail:1273360266@qq.com
作者简介:尚涛(1980-),男,吉林省白城市人,副主任医师,医学硕士,主要从事糖尿病血管并发症方面的研究。
基金资助:
吉林省科技厅科技发展计划项目资助课题（20130413006GH）

Changes of serum levels of IGF-1, IGFBP-3 and plasma proteins of patients with diabetic foot before and after recombinant human growth hormone therapyand their significances

SHANG Tao, REN Yanli, LI Jing, ZHANG Ying

Department of Endocrinology, People's Hospital of Jilin Province, Changchun 130021, China

Received:2017-03-29 Online:2017-11-28 Published:2017-12-01

摘要/Abstract

摘要： 目的：检测糖尿病足（DF）患者血清中胰岛素样生长因子1（IGF-1）、胰岛素样生长因子结合蛋白3（IGFBP-3）和血浆蛋白的水平，探讨重组人生长激素（rhGH）对DF患者的治疗作用。方法：选取DF患者（DF组，n=40）、糖尿病患者（DM组，n=40）和健康成年人（正常对照组，n=40）为研究对象。将DF组患者按照患者意愿分为rhGH治疗组和常规治疗组，每组各20例。rhGH治疗组患者给予0.4IU·kg^-1·d^-1rhGH注射液，皮下注射，每个疗程15d，2个疗程间隔5d，总计3个疗程；常规治疗组患者给予同等剂量生理盐水皮下注射。比较各组研究对象一般临床资料、治疗前后血清IGF-1和IGFBP-3水平、患者病情分级构成、血浆蛋白总蛋白（TP）、转铁蛋白（TRF）、空腹血糖（FBG）水平及DF组患者和正常对照组研究对象rhGH治疗有效率和创面愈合时间。结果：DF组患者血清IGF-1和IGFBP-3水平明显低于DM组和正常对照组（P<0.01）；DM组患者血清IGF-1和IGFBP-3水平明显低于正常对照组（P<0.05）。rhGH治疗组患者治疗后血清IGF-1、IGFBP-3和血浆TP、TRF水平与治疗前比较差异有统计学意义（P<0.05），且均高于常规治疗组治疗后的相应指标（P<0.05）；DM组和正常对照组研究对象FBG水平比较差异无统计学意义（P<0.05）。rhGH治疗组患者有效率明显高于常规治疗组（P<0.05）。结论：DF患者经rhGH治疗后有效率提高，适合临床推广。

关键词: 重组人生长激素, 胰岛素样生长因子1, 血浆总蛋白, 转铁蛋白, 糖尿病足

Abstract: Objective:To detect the levels of serum insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3 (IGFBP-3) and the plasma proteinsof the patients with diabetic foot (DF), and to investigate the therapeutic effect of recombinant human growth hormone (rhGH) in the DFpatients. Methods:The DF patients (DF group,n=40), diabetes mellitus patients (DM group,n=40) and healthy adults (normal control group,n=40) were selected. The patients in DF group were divided into rhGH treatment group and conventional treatment group according to the treatment willingness(n=20).The patients in rhGH treatment group recevied 0.4 IU·kg^-1·d^-1 rhGH injection subcutaneously for 15 d, the interval between two courses was 5 d,with a total of 3 courses of treatment. The patients in convention treatment group received subcutaneous injection of the same dose of saline.The general clinical data before and after treatment, the serum IGF-1 and IGFBP-3 levels,the constitution of disease grading of patients, the levels of plasma TP and TRF, FBG, and the efficiency rate and wound healing time of the subjects in DF group and normal control group were detected. Results:The levels of serum IGF-1 and IGFBP-3 of the patients in DF group were significantly lower than those in DM group and normal control group (P<0.01); the serum levels of IGF-1 and IGFBP-3 of the patients in DM group were significantly lower than those in normal control group (P<0.05).After treatment, the serum levels of IGF-1, IGFBP-3 and plasma TP,TRF of the patients in rhGH treatment group were significantly increased compared with before treatment (P<0.05),and they were higher than those in conventional treatment group after treatment (P<0.05).There was no significant difference in the FBG levels of the subjects between DM group and normal control group(P>0.05).The effective rate of the patients in rhGH treatment group was higher than that in conventional treatment group (P<0.05). Conclusion:The efficiency of DF patients can be improved after treated with rhGH, and it is suitable for clinical promotion.

Key words: total protein, recombinant human growth hormone, insulin-like growth factor 1, transferrin, diabetic foot

中图分类号:

R587.1

尚涛, 任艳丽, 李静, 张英. 重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义[J]. 吉林大学学报(医学版), 2017, 43(06): 1209-1214.

SHANG Tao, REN Yanli, LI Jing, ZHANG Ying. Changes of serum levels of IGF-1, IGFBP-3 and plasma proteins of patients with diabetic foot before and after recombinant human growth hormone therapyand their significances[J]. Journal of Jilin University Medicine Edition, 2017, 43(06): 1209-1214.

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重组人生长激素治疗前后糖尿病足患者血清中IGF-1、IGFBP-3和血浆蛋白水平的变化及其意义

Changes of serum levels of IGF-1, IGFBP-3 and plasma proteins of patients with diabetic foot before and after recombinant human growth hormone therapyand their significances

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