中间型血友病患者四肢主要关节功能状况分析

doi:10.13481/j.1671-587x.20180323

吉林大学学报(医学版) ›› 2018, Vol. 44 ›› Issue (03): 579-584.doi: 10.13481/j.1671-587x.20180323

中间型血友病患者四肢主要关节功能状况分析

马乐^1,2, 范猛², 薛峰³, 姜文学²

1. 天津医科大学一中心临床学院骨科, 天津 300070;
2. 天津市第一中心医院骨科, 天津 300192;
3. 中国医学科学院北京协和医学院血液学研究所血液病医院骨科, 天津 300020

收稿日期:2017-12-27 出版日期:2018-05-28 发布日期:2018-05-31
通讯作者: 姜文学,主任医师,硕士研究生导师(Tel:020-23626353,E-mail:jiangwenxue1920@163.com) E-mail:jiangwenxue1920@163.com
作者简介:马乐(1990-),男,吉林省延吉市人,在读医学硕士,主要从事骨关节炎诊治方面的研究。
基金资助:
天津市卫计委公关项目资助课题（16KG102）

Analysis on functional status of major joints in limbs of moderate hemophilia patients

MA Le^1,2, FAN Meng², XUE Feng³, JIANG Wenxue²

1. Department of Orthopedics, First Central Clinical College, Tianjin Medical University, Tianjin 300070, China;
2. Department of Orthopedics, Tianjin First Central Hospital, Tianjin 300192, China;
3. Department of Orthopedics, Institute of Hematology & Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China

Received:2017-12-27 Online:2018-05-28 Published:2018-05-31

摘要/Abstract

摘要： 目的：分析93例血友病患者四肢主要关节功能状况，提高对该病的认识和管理。方法：93例中间型（FVⅢ：C/FⅨ：C1%~5%）血友病患者根据患者年龄分为7个亚组，即<10岁组，10~20岁组，20~30岁组，30~40岁组，40~50岁组，50~60岁组，>60岁组。统计患者各关节血友病性关节炎累及率，采用血友病关节健康评分（HJHS）评估患者四肢主要关节功能状况。结果：中间型和重型血友病患者各关节累及率比较差异均无统计学意义（P>0.05）。中间型血友病患者平均HJHS与重型血友病患者比较差异无统计学意义（P=0.157）。20~30岁重型血友病患者平均HJHS高于中间型血友病患者（Z=-2.127，P=0.033）。10~20岁组和20~30岁组中间型和重型血友病患者膝关节HJHS比较差异有统计学意义（Z_10~20=-2.710，P_10~20=0.007；Z_20~30=-2.384，P_20~30=0.017），其他各个年龄段中间型和重型血友病患者HJHS比较差异无统计学意义（P>0.05）。结论：中间型血友病患者出血治疗现状较差，采取按需治疗和预防治疗相结合的方法可有效减少关节出血，有效保证血友病患者关节功能，提高患者生活质量。

关键词: 按需治疗, 中间型血友病, 血友病性关节炎, 血友病

Abstract: Objective: To detect the functional status of major joints in limbs of the patients with moderate hemophilia,and to improve the understanding and management of hemophilia. Methods: A total of 93 patients with moderate hemophilia (FVⅢ:C/FⅨ:C:1%-5%) were divided into seven subgroups according to their ages:<10 years,10-20 years,20-30 years,30-40 years,40-50 years,50-60 years,and > 60 years. The joint involvement rates of patients were observed and the joint function was evaluated using Hemophilia Joint Heath Score (HJHS). Results: Compared with moderate hemophilia group,the difference in the involvement rate of hemophilic arthritis of the patients in severe hemophilia group was not significant(P>0.05).The mean HJHS of the patients in moderate hemophilia group and severe hemophilia group had no statistical difference (P=0.157).In 20-30 years group,the mean HJHS of the patients in severe hemophilia group was higher than that in moderate hemophilia group(Z=-2.127,P=0.033). In 10-20 years and 20-30 years groups,there were statistically significant differences in the HJHS of knee joint between moderate hemophilia group and severe hemophilia group(Z_10-20=-2.710,P_10-20=0.007;Z_20-30=-2.384,P_20-30=0.017).There were no significant differences in the HJHS of the patients in moderate hemophilia group and severe hemophilia group at the different ages (P>0.05). Conclusion: The hemorrhage treatment status of moderate hemophilia patients is poor.The combination of on-demand treatment and preventive treatment can reduce the joint hemorrhage,and guarantee the joint function of hemophilia patients effectively and improve the life quality of the patients.

Key words: on-demand treatment, hemophilia, hemophilic arthritis, moderate hemophilia

中图分类号:

R684.2

马乐, 范猛, 薛峰, 姜文学. 中间型血友病患者四肢主要关节功能状况分析[J]. 吉林大学学报(医学版), 2018, 44(03): 579-584.

MA Le, FAN Meng, XUE Feng, JIANG Wenxue. Analysis on functional status of major joints in limbs of moderate hemophilia patients[J]. Journal of Jilin University Medicine Edition, 2018, 44(03): 579-584.

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中间型血友病患者四肢主要关节功能状况分析

Analysis on functional status of major joints in limbs of moderate hemophilia patients

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