关键词: 氟, 再矿化, 显微放射照相

Abstract: To evaluate the remineralization effect of casein phosphopeptide amorphous calcium phosphate(CPP-ACP) and fluoride complex on artificial enamel subsurface white spot lesions in vitro in order to provide a new method to treat the postorthodontic enamel demineralization.Methods Extracted premolar teeth for orthodontic reason were immersed into lactic acid gel to prepare artificial white spot lesions.Then the specimens were randomly assigned to seven groups: 5.0%CPP-ACFP group,1.0% CPP-ACP group,0.1% CPP-ACPgroup,calcium phosphate saturated solution group,calcium phosphate saturated solution plus fluorid group,deionized water group.Lesion depths and mineral loss were quantitatively determined by microradiography in various groups.Results The lesion depths and mine ral loss after remineralization in each group were significantly reduced(P<0.05) except deionized water group; the lesion depth and mineral loss in 5.0%CPP-ACFP group were significantly lower than those in the other groups(P<0.05,P<0.01); the lesion depth and mineral loss in 5.0%CPP-ACP group were markedly reduced than those in 0.1%CPP-ACP group(P<0.05,P<0.01) .There were no significant differences between 0.1% CPP-ACP group,calcium phosphate saturated solution group and calcium phosphate saturated solution plus fluorid group(P>0.05),but the lesion depths and mineral loss in these three groups were significantly lower than those in deionized water group(P<0.05,P<0.01).Conclusion CPP-ACP has the ability of promoting remineralization of enamel artificial white spot lesions which can be enhanced by fluorid.The remineralization ability depends on the concentration of calcium phosphate stabilized by CPP-ACP.

Key words: fluoride, remineralization, microradiography