地氟醚药理特性及其临床应用的研究进展

doi:10.13481/j.1671-587x.20180246

摘要/Abstract

摘要： 地氟醚是一种新型的吸入性麻醉剂，其结构虽与七氟醚等卤代吸入性麻醉剂相似，但药理特性却有较大差异。地氟醚血气分配系数和组织溶解度是现有吸入性麻醉剂中最低的，与其他吸入性麻醉剂比较，地氟醚具有麻醉深度易于调控和苏醒快的特点。近几年，国外对于地氟醚在临床麻醉中的应用以及与其他药物的协同作用研究越来越多，国内对地气氟醚的认识和应用较局限，且近年来尚无较全面的相关综述报道。本文从地氟醚药物结构和药理特性入手，结合近几年国内外的研究，分析地氟醚的临床应用进展，重点对地氟醚与其他吸入性麻醉剂的药理特性进行对比，分析其差异性。本文通过对地氟醚的药效学和药代动力学特点进行阐述，归纳其对呼吸、循环和中枢神经系统的作用机制及临床效果；并从老年、肥胖、儿童和肝肾功能不全等特殊人群，以及日间手术、长时间手术等特殊手术的角度，对地氟醚的临床适用范围进行总结，为地氟醚在临床应用的合理适用范围提供参考。

关键词: 地氟醚, 吸入性麻醉剂, 药效学, 药代动力学

中图分类号:

R614.2

刘莹瑞, 段立波. 地氟醚药理特性及其临床应用的研究进展[J]. 吉林大学学报(医学版), 2018, 44(02): 448-454.

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