非标准D-氨基酸对细菌生物膜抑制作用的研究进展

doi:10.13481/j.1671-587x.20190242

摘要/Abstract

摘要： 口腔多种炎症性疾病与细菌生物膜的形成有关。特定的D-氨基酸被证实在细菌生物膜的形成和（或）裂解过程中有显著作用。非标准D-氨基酸可通过蛋白Ldts介导其整合到细胞壁肽聚糖，取代第4位点D-丙氨酸和（或）细胞质连接酶Ddl、MurF催化肽聚糖第5位点前体的形成，非标准D-氨基酸将特定的转运蛋白的转运，最终取代第5位点上的D-丙氨酸，从而改变肽聚糖结构并有效地抑制细菌生物膜的形成和（或）裂解已形成的生物膜。本文作者将非标准D-氨基酸对生物膜的抑制作用及其作用机制做一综述。

关键词: 非标准D-氨基酸, 生物膜, 肽聚糖, 细胞壁, 细菌

中图分类号:

Q935

王鹤龄, 齐华, 李保胜, 蔡青, 全旭, 许彤彤, 崔云霞, 孟维艳. 非标准D-氨基酸对细菌生物膜抑制作用的研究进展[J]. 吉林大学学报(医学版), 2019, 45(02): 445-449.

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