[1] AN YN,LI Y,WANG X Y,et al.Cordycepin reduces weight through regulating gut microbiota in high-fat diet-induced obese rats[J].Lipids Health Dis,2018,17(1):276. [2] YU O M,BROWN J H.G protein-coupled receptor and RhoA-stimulated transcriptional responses: links to inflammation,differentiation,and cell proliferation[J].Mol Pharmacol,2015,88(1):171-180. [3] MONAGHAN-BENSON E,WITTCHEN E S,DOERSCHUK CM,et al.A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts[J].Mol Biol Cell,2018,29(18):2165-2175. [4] MANICKAM N,PATEL M,GRIENDLING K K,et al.RhoA/Rho kinase mediates TGF-β1-induced kidney myofibroblast activation through Poldip2/Nox4-derived reactive oxygen species[J].Am J Physiol Renal Physiol,2014,307(2):F159-F171. [5] FENG S,ZOU L,WANG H J,et al.RhoA/ROCK-2 pathway inhibition and tight junction protein upregulation by catalpol suppresses lipopolysaccaride-induced disruption of blood-brain barrier permeability[J].Molecules,2018,23(9):E2371. [6] TAKIYAMA Y,SERA T,NAKAMURA M,et al.Impacts of diabetes and an SGLT2 inhibitor on the glomerular number and volume in db/db mice,as estimated by synchrotron radiation micro-CT at spring-8[J].EBioMedicine,2018,36:329-346. [7] WU W,HU W,HAN W B,et al.Inhibition of Akt/mTOR/p70S6K signaling activity with huangkui capsule alleviates the early glomerular pathological changes in diabetic nephropathy[J].Front Pharmacol,2018,9:443. [8] BAO J F,SHI Y F,TAO M,et,al.Pharmacological inhibition of autophagy by 3-MA attenuates hyperuricemic nephropathy[J].Clin Sci,2018,132(21):2299-2322. [9] KOVESDY C P,FURTH S L,ZOCCALI C.Obesity and kidney disease: hidden consequences of the epidemic[J].Braz J Med Biol Res,2017,50(5):e6075. [10] BARTON M,SOROKIN A.Endothelin and the glomerulus in chronic kidney disease[J].Semin Nephrol,2015,35(2):156-167. [11] NIU H L,LI Y,LI H B,et al.Matrix metalloproteinase 12 modulates high-fat-diet induced glomerular fibrogenesis and inflammation in a mouse model of obesity[J].Sci Rep,2016,6:20171. [12] JERUSCHKE S,BÜSCHER A K,OH J,et al.Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling[J].PLoS One,2013,8(2):e55980. [13] BABA I,EGI Y,UTSUMI H,et al.Inhibitory effects of fasudil on renal interstitial fibrosis induced by unilateral ureteral obstruction[J].Mol Med Rep,2015,12(6): 8010-8020. [14] 刘恒.Rho/Rho激酶信号通路和肝细胞生长因子在2型糖尿病大鼠肾病中的作用[D].石家庄:河北医科大学,2012. [15] XIE X,CHEN Q,TAO J.Astaxanthin promotes Nrf2/ARE signaling to inhibit HG-induced renal fibrosis in GMCs[J].Mar Drugs,2018,16(4):117. [16] 谌祖江.芪丹地黄汤抑制糖尿病肾病肾脏纤维化的作用和机制研究[D].广州:南方医科大学,2018. [17] KOLAVENNU V,ZENG L X,PENG H,et al.Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control[J].Diabetes,2008,57(3):714-723. [18] 马东蔚,王秋月,马小羽.法舒地尔通过Rho/ROCK信号通路对高糖培养人肾小球系膜细胞炎症反应及纤维化的影响[J].中华内科杂志,2011,50(7):580-584. [19] PENG F F,WU D C,GAO B,et al.RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease[J].Diabetes,2008,57(6):1683-1692. [20] DANIELSSON F,PETERSON M K,CALDEIRA ARAUJO H,et al.Vimentin diversity in health and disease[J].Cells,2018,7(10): E147. [21] SUBATHRA M,KORRAPATI M,HOWELL L A,et al. Kidney glycosphingolipids are elevated early in diabetic nephropathy and mediate hypertrophy of mesangial cells[J].Am J Physiol Renal Physiol,2015,309(3):F204-F215. [22] 沈健,臧东钰,李晓明.高脂饮食诱导的C57BL/6J幼鼠肾足细胞中Synaptodin的表达及意义[J].解放军医学院学报,2015,36(9):940-943. |