吉林大学学报(医学版) ›› 2024, Vol. 50 ›› Issue (5): 1474-1480.doi: 10.13481/j.1671-587X.20240535

• 综述 • 上一篇    

CXC趋化因子受体3对神经系统疾病发生发展影响的研究进展

刘文慧1,于淼2,郭莹1,刘宇朋1,幸洋3,洪新雨3,崔佳乐1()   

  1. 1.吉林大学基础医学院组织学与胚胎学系,吉林 长春 130021
    2.吉林大学第一医院公共实验平台,吉林 长春 130021
    3.吉林大学第一医院神经外科,吉林 长春 130021
  • 收稿日期:2023-05-08 出版日期:2024-09-28 发布日期:2024-10-28
  • 通讯作者: 崔佳乐 E-mail:cuijiayue@jlu.edu.cn
  • 作者简介:刘文慧(2000-),女,山东省德州市人,在读硕士研究生,主要从事神经系统肿瘤基础和临床方面的研究。
  • 基金资助:
    吉林省科技厅自然科学基金项目(20200201491JC);吉林省财政厅医疗卫生人才专项(JLSWSRCZX2023-24)

Research progress in effect of CXC chemokine receptor 3 on occurrence and development of nervous system diseases

Wenhui LIU1,Miao YU2,Ying GUO1,Yupeng LIU1,Yang XING3,Xinyu HONG3,Jiale CUI1()   

  1. 1.Department of Histology and Embryology,School of Basic Medical Sciences,Jilin University,Changchun 130021,China
    2.Core Facility,First Hospital,Jilin University,Changchun 130021,China
    3.Department of Neurosurgery,First Hospital,Jilin University,Changchun 130021,China
  • Received:2023-05-08 Online:2024-09-28 Published:2024-10-28
  • Contact: Jiale CUI E-mail:cuijiayue@jlu.edu.cn

摘要:

趋化因子及其受体在神经系统疾病中起重要作用,其中CXC趋化因子受体3(CXCR3)是细胞之间传递信息的重要介质,不仅在诱导炎性趋化和肿瘤细胞恶性生物学行为中起作用,在神经系统疾病中也发挥重要调控作用。CXCR3及其配体可直接或间接参与神经炎症和神经免疫等反应,有望成为多发性硬化、阿尔茨海默病及胶质瘤等疾病治疗的靶点。现对CXCR3及其相应配体在神经系统疾病如多发性硬化、神经系统肿瘤、神经退行性疾病和神经性疼痛等方面的表达及影响,及其与CXCR3配体间的关联进行综述,揭示CXCR3与疾病关系的机制,探讨CXCR3作为早期诊断生物标志物和药物干预靶点的潜力,为CXCR3对神经系统疾病发生发展影响的研究提供参考。

关键词: 趋化因子受体3, CXC趋化因子受体3配体, 神经系统炎症, 神经系统肿瘤, 神经退行性疾病

Abstract:

Chemokines and their receptors play crucial roles in nervous system diseases, among which the CXC chemokine receptor 3 (CXCR3) is an important mediator of intercellular communication. CXCR3 not only participates in inflammatory chemotaxis and malignant behaviors of tumor cells but also regulates the neurologic diseases. CXCR3 and its ligands directly or indirectly contribute to neuroinflammation and neuroimmunity, and potentially serve as therapeutic targets for diseases like multiple sclerosis, Alzheimer’s disease, and glioma and so on. This review discusses the expression and impact of CXCR3 and its ligands in neurological diseases such as multiple sclerosis, neurologic tumors, neurodegenerative diseases, and neuropathic pain, as well as their associations with CXCR3 ligands. Understanding the mechanisms linking CXCR3 to these diseases could facilitate its potential as an early diagnostic biomarker and a target for drug intervention, and provide the basis of studying the occurrence and developmant of nervous system disease.

Key words: Chemokine receptor 3, CXC chemokine receptor 3 ligands, Neurological inflammation, Neurological tumor, Neurodegenerative diseases

中图分类号: 

  • R741.02