血清生殖激素水平与精子密度的关系

J4 ›› 2009, Vol. 35 ›› Issue (3): 530-533.

血清生殖激素水平与精子密度的关系

李环^1,2, 高久春¹, 郭航³, 常艳¹, 刘睿智¹, 邢沈阳³

1.吉林大学基础医学院细胞生物学教研室吉林省生殖医学研究所|吉林长春 130021；2.北华大学公共卫生学院环境卫生学教研室|吉林吉林 132021；3.吉林大学第二医院泌尿外科|吉林长春 130041；4.吉林大学畜牧兽医学院遗传育种与繁殖系|吉林长春 130061

收稿日期:2008-10-23 出版日期:2009-05-28 发布日期:2009-08-14
通讯作者: 邢沈阳 E-mail:lrz420 @126.com
作者简介:李环（1978-）|男|吉林省长春市人|在读医学硕士|主要从事男性生殖医学方面的研究。
基金资助:
吉林省科技厅科研基金资助课题（200505140）

Relationships between serum reproductive hormone levels and sperm density

LI Huan^1,2, GAO Jiu-Chun¹, GUO Hang³, CHANG Yan¹, LIU Rui-Zhi¹, GENG Chen-Yang⁴

1.Department of Cell Biology,School of Basic Medical Sciences,Jilin University, |Institute for Reproductive Medicine of Jilin Province| Changchun 130021|China;2. Department of Environment Hygience,School of PublicHealth,Beihua University,Jilin 132021,China;3.Department of Urology,Second Hospital,Jilin University| Changchun 130041,China ；4. Department of Animal Genetics and Breeding,College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,Chin

Received:2008-10-23 Online:2009-05-28 Published:2009-08-14

摘要/Abstract

摘要：

目的：探索血清生殖激素卵泡刺激素（FSH）、黄体生成素（LH）、睾酮（T）及抑制素B（INHB）水平与精子密度的关系，阐明血清生殖激素水平对男性不育的诊断意义。方法：男性不育患者150例（少精子症50例，严重少精子症50例，无精子症50例），对照组（正常生育组）50例，采用计算机辅助精液分析检测精子密度，采用放射免疫分析法检测血清生殖激素水平。结果：与正常对照组比较，少精子症组、严重少精子组、无精子症组FSH、LH水平均显著增高(P<0.01)，INHB水平显著降低(P<0.01)；无精子症组与少精子症组、严重少精子组比较FSH、LH水平均增高(P<0.01)，INHB水平显著降低(P<0.01)。精子密度分别与FSH、LH呈负相关关系(r=－0.562,P<0.001;r=－0.347,P<0.001),精子密度与INHB呈正相关关系(r=0.623,P<0.001)，与T无相关性（r=0.080,P>0.05）。结论：血清FSH及LH水平增高提示睾丸功能有损害，精子密度逐渐降低；INH-B水平与精子密度密切相关，可直接反应睾丸生精功能。

关键词: 男性不育；精子密度；生殖激素

Abstract:

To study the relationships between serum follicle stimulating hormone(FSH),luteinizing hormone (LH),testosterone (T),inhibin B(INHB) and sperm density and the significance of serum reproductive hormones in diagnosis of male infertility.Methods 150 patients with male infertility were selected,including 50 cases of oligospermia,50 cases of severe oligospermia,50 cases of azoospermia,and 50 healthy subjects were used as controls(normal sperm density group).Sperm density was detected by computer assisted sperm analysis(CASA).The serum FSH,LH,T,INHB levels were detected by radioimmunoassay.
Results The serum FSH and LH in oligospermia，severe oligospermia and azoospermia groups were significantly higher than those in normal sperm density group (P<0.01)，however the serum INH-B levels were significantly lower (P<0.01).The serum FSH and LH levels in azoospermia group were significantly higher than those in oligospermia and severe oligospermia groups (P<0.01),while the serum INH-B level was significantly lower (P<0.01).There were significantly negative correlations between sperm density and the levels of FSH，LH (r=－0.562,P<0.001;r=－0.347,P<0.001). There was significantly positive correlation between sperm density and INHB (r=0.623,P<0.001),the sperm density had no correlation with T（r=0.080,P>0.05）.
Conclusion There are negative correlations between the levels of FSH, LH and sperm density;and the level of INHB is positively correlated to the sperm density.

Key words: male infertility；sperm density；reproductive hormones

中图分类号:

R698.2

李环, 高久春, 郭航, 常艳, 刘睿智, 邢沈阳. 血清生殖激素水平与精子密度的关系[J]. J4, 2009, 35(3): 530-533.

LI Huan, GAO Jiu-Chun, GUO Hang, CHANG Yan, LIU Rui-Zhi, GENG Chen-Yang. Relationships between serum reproductive hormone levels and sperm density[J]. J4, 2009, 35(3): 530-533.