人源化小鼠模型构建和应用的研究进展

doi:10.13481/j.1671-587x.20180340

摘要/Abstract

摘要： 人源化小鼠是指带有功能性的人类基因、细胞或组织的小鼠模型，通常被用于人类疾病体内研究的活体替代模型，是利用转基因或同源重组的方法将人类基因"放置"在小鼠模型上所制备的模型，这类小鼠模型在模拟某些人类疾病时有效性较高。人源化小鼠模型在艾滋病、癌症、传染病和血液病研究领域等均有广泛的应用。具有人造血免疫系统组成的人源化小鼠模型已经被证明在解码人类疾病奥秘中具有巨大的优势和广泛的应用前景。本文从免疫系统人源化小鼠模型演变的历史过程、具体的分类方法及模型的应用等几个方面进行综述。

关键词: 自身免疫性疾病, 人源化小鼠, 传染性疾病, 肿瘤

中图分类号:

R392.4

陈冰, 刘昊川, 李龙云, 赵国庆, 王震, 杨永广, 李凯, 胡正. 人源化小鼠模型构建和应用的研究进展[J]. 吉林大学学报(医学版), 2018, 44(03): 667-674.

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