骨髓前列腺特异抗原诊断前列腺癌骨转移

doi:日本政府JICA基金资助课题

骨髓前列腺特异抗原诊断前列腺癌骨转移

张慕淳¹，孔祥波¹，王伟华¹，桑原正明²，川村贞文²

1. 吉林大学中日联谊医院泌尿外科，吉林长春130031；2. 日本宫城县立癌中心泌尿器科,日本仙台9800075

收稿日期:2003-09-16 修回日期:1900-01-01 出版日期:2004-07-28 发布日期:2004-07-28

Bone marrow prostate specific antigen in diagnosisof prostatic cancer bone metastasis

ZHANG Mu-chun¹，KONG Xiang-bo¹，WANG Wei-hua¹，MASAAKI Kuwahara²，YASUYOSHI Skaua²

1. Department of Urology,China-Japan Union Hospital, Jilin University, Changchun 130031, China;2. Department of Urology ,Miyagi Prof Gan Center Hospital, Sendai 9800075，Japan

Received:2003-09-16 Revised:1900-01-01 Online:2004-07-28 Published:2004-07-28

摘要/Abstract

摘要： 目的：探讨检测骨髓前列腺特异抗原（PSA）筛选前列腺癌骨转移的价值。方法：选择20例前列腺癌患者，按同位素骨扫描结果，分为无骨转移的阴性组（8例）和有骨转移的阳性组（12例），20例良性前列腺增生症患者为对照组，分别检测骨髓及血清中PSA值，并测定骨髓PSA与血清PSA的比值。结果：有骨转移组和无骨转移组骨髓PSA值差异有显著性（P<0.05），以骨髓/血清PSA比值为0.70作为筛选骨转移阳性的参考值时，预测前列腺癌骨转移的敏感性为78%，特异性为86%，准确率为73%。结论：骨髓PSA与前列腺癌骨转移有关，可作为前列腺癌骨转移的肿瘤标记物，骨髓/血清PSA比值0.70可作为骨转移的筛检指标之一。

关键词: 肿瘤转移, 前列腺特异抗原, 骨肿瘤, 继发性

Abstract: Objective To investigate the clinical diagnostic value of bone marrow prostate specific antigen (PSA) in bone metastasis of prostatic cancer. Methods Twenty cases of prostatic cancer were divided into positive bone scanning group (n=12) and negative bone scanning group (n=8) according to the results of isotope bone scanning,and 20 cases of benign prostatic hyperplasia were used as control.The levels of PSA in bone marrow and serum were measured in all patients to study the correlationship of bone marrow PSA and bone metastasis, and the ratio of bone marrow PSA to serum PSA was calculated. Results The level of PSA in bone marrow in positive bone scanning group were statistically higher than those in negative bone scanning group and control group (P<0.05)). The diagnostic ratio of bone marrow PSA to serum PSA had been set to 0.70, the sensitivity to predict bone metastasis was 78%, the specificity was 86%, the accuracy was 73%. Conclusion The level of PSA in bone marrow has close correlation with bone metastasis of prostatic cancer and it is a marker of bone metastasis of prostate cancer. The ratio of 0.70 of bone marrow PSA to serum PSA can be used as a index to diagnose bone metastasis.

Key words: neoplasms metastasis, prostate specific antigen, bone neoplasms, secondary

中图分类号:

R737.25

张慕淳，孔祥波，王伟华，桑原正明，川村贞文. 骨髓前列腺特异抗原诊断前列腺癌骨转移[J]. J4, 2004, 30(4): 600-602.

ZHANG Mu-chun，KONG Xiang-bo，WANG Wei-hua，MASAAKI Kuwahara，YASUYOSHI Skaua. Bone marrow prostate specific antigen in diagnosisof prostatic cancer bone metastasis[J]. J4, 2004, 30(4): 600-602.

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