关键词: 乳腺肿瘤, 微血管密度, 肿瘤转移

Abstract: Objective To study the expression of epithelial-cadherin (E-cd) in breast cancer cells and the microvessel density (MVD) in breast cancer mesenchyma, and to analyze the correlation between two factors and metastasis in breast cancer. Methods Seventy breast cancer cases with or without lymph node metastasis were selected. The routine histopathology was used to make pathological diagnosis and histological type. Immunohistochemical method was applied to detect the expressions of E-cd and CD34. Results The expression of E-cd was relative to the lymph node metastasis (P<0.05) and irrelevant to the histological types of breast cancer. The MVD in breast cancer with lymph node metastasis was significantly higher than that without lymph node metastasis, and also was irrelevant to the histological types of breast cancer. When the grade of the MVD in breast cancer mesenchyma was low, there was no difference of MVD between lymph node with metastasis and without metastasis(P>0.5),but it was relative to the MVD of lymph node(P<0.001). Conclusion Breast cancer metastasis is dependent on not only the E-cd gene mutation but also the mesenchymal MVD. Therefore, the expression of E-cd in breast cancer cells and the examination of MVD can be used as a reference marker to diagnose the breast cancer metastasis.

Key words: breast neoplasms, microvessel density, neoplasms metastasis