复方刺五加注射液对药物诱发实验性心律失常的影响

doi:吉林省科技厅基金资助课题（19990310-01）

复方刺五加注射液对药物诱发实验性心律失常的影响

王黎¹，张潇月¹，曲绍春²，于小风²，徐华丽²，睢大员²

(1.吉林大学第一医院干部病房，吉林长春 130021；2.吉林大学药学院药理学教研室, 吉林长春 130021

收稿日期:2006-10-08 修回日期:1900-01-01 出版日期:2007-07-28 发布日期:2007-07-28
通讯作者: 睢大员

Effects of Compound Acanthopanax Senticosus Injection on experimental arrhythmia induced with medicine

WANG Li¹,ZHANG Xiao-yue¹,QU Shao-chun²,YU Xiao-feng²,XU Hua-li²,SUI Da-yuan²

(1.Department of Cadre Ward, First Hospital,Jilin University,Changchun 130021,China； 2.Department of Pharmacology,School of Pharmacy,Jilin University,Changchun 130021,China)

Received:2006-10-08 Revised:1900-01-01 Online:2007-07-28 Published:2007-07-28
Contact: SUI Da-yuan

摘要/Abstract

摘要： 目的: 观察复方刺五加注射液（CASI）对药物诱发实验性心律失常的影响。方法：制备氯化钡(BaCl₂)、哇巴因及乌头碱诱导的大鼠及豚鼠实验性心律失常模型，CASI按25、50、100 mg•kg^-1分为3个剂量组，舌下静脉给药1次，不给CASI作为对照组，记录大鼠给BaCl₂后心律失常的发生率、出现时间、持续时间及动物的死亡率；观察豚鼠及大鼠出现室性早搏（VP）、室性心动过速（VT）、心室颤动（VF）及心脏停搏（CA）时哇巴因及乌头碱的用量。结果：与对照组比较，CASI 25 、50、100 mg•kg^-1组大鼠BaCl₂性心律失常的发生率降低（P<0.05），出现时间推迟（P<0.01），持续时间缩短（P<0.05），死亡率减少（P<0.01）；CASI 50、100 mg•kg^-1组豚鼠对哇巴因中毒诱发VP、VT、VF及CA的耐受剂量高于对照组（ P<0.05或P<0.01）；CASI 100 mg•kg^-1组大鼠对乌头碱诱发VP、VT及VF的耐受剂量高于对照组（P<0.05），并且明显优于阳性药维拉帕米注射液。结论：CASI对多种药物诱发的实验性心律失常均具有明显保护作用，其对抗Ca2+性心律失常的作用明显优于Na+性心律失常，提示CASI可能为钙通道阻滞剂。

关键词: 心律失常, 氯化钡, 哇巴因, 乌头碱

Abstract: To observe the effects of Compound Acanthopanax Senticosus Injection (CASI) on experimental arrhythmia induced with medicine in rats and cobayaes. Methods The experimental arrhythmia models were induced with barium chloride (BaCl₂),uabaina and aconitine in rats and cobayaes.The incidence rate and mortality rate of arrhythmia，the emergence time and the duration of arrhythmia induced with BaCl₂ were recorded in rats pretreated with CASI (in dosages of 25,50, and 100 mg•kg-1 sublingual vein injection).At the same time,the dosages of uabaina and aconitine were observed when the ventricular premature contraction (VP),ventricular tachycardia (VT),ventricular fibrillation (VF) and cardiac asystole(CA) were appeard in rats and cobayaes pretreated with CASI (in dosages of 25,50, and 100 mg•kg^-1 sublingual vein injection). Results Compared with control group,the incidence rate of arrhythmia induced with BaCl₂ was lowered (P<0.05),the emergence time of arrhythmia was delayed(P<0.01),the duration of arrhythmia was shortened(P<0.05),and mortality rate of arrhythmia was decreased significantly (P<0.01) in rats pretreated with CASI in dosages of 25,50, and 100 mg•kg^-1sublingual vein injection.The tolerance doses of cobayaes on VP,VT,VF and CA induced with uabaina were significantly higher in 50 and 100 mg•kg^-1 CASI groups than control group (P<0.05 or P<0.01), while the tolerance doses of rats on VP,VT and VF induced with aconitine were also significantly higher in 100 mg•kg^-1 CASI group than control group (P<0.05). Conclusion CASI have a significantly protective effect on experimental arrhythmia induced with medicine in rats and cobayaes,its effect on calcium channel is more better than on natrium channel.The results show that CASI may be calcium channel blocker.

Key words: arrhythmia , barium chloride, uabaina , aconitine

中图分类号:

R286.24

王黎，张潇月，曲绍春，于小风，徐华丽，睢大员. 复方刺五加注射液对药物诱发实验性心律失常的影响[J]. J4, 2007, 33(4): 678-681.

WANG Li,ZHANG Xiao-yue,QU Shao-chun,YU Xiao-feng,XU Hua-li,SUI Da-yuan. Effects of Compound Acanthopanax Senticosus Injection on experimental arrhythmia induced with medicine[J]. J4, 2007, 33(4): 678-681.

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