关键词: 系统性, 抗原, 分化, B淋巴细胞, 抗原, 分化, T淋巴细胞

Abstract: Objective To study the expressions of immune cell differentiation antigens in patients with active and inactive stages of systemic lupus erythematosus (SLE). Methods The expressions of T, B, NK, plasma and neutrophil cell differentiation antigens were studied with 18 kinds of monoclonal antibodies using indirect and direct immunofluorescence technique by cytometry from 30 normal controls and 43 SLE patients. Results The expressions of CD2, CD3, CD4, CD45RA, CD56, CD89 on immune cells were down-regulated in active stage of SLE; while the expressions of CD8, CD10, CD23, CD25, CD29, CD138 were up-regulated; other cell expressions showed no significant differences from normal control. In inactive stage the expressions of some cells reached normal except CD3, CD4, CD23, CD25, CD29, CD45RA, and CD89. The CD89 level in patients with active SLE was negatively correlated with the extent of hematuria,the correlation coefficients before and after therapy were -0.5821 and -0.7948, respectively.Conclusion The expressions of T, B, NK, plasma and neutrophil differentiation antigens are abnormal in SLE patients, especially in active stage of disease.

Key words: systemic, antigens, differentiation, B-lymphocyte, antigens, differentiation, T-lymphocyte